oxBS-Seq Breaks Through 5hmC Sequencing BarrierApril 26, 20125-Hydroxymethylcytosine (5hmC) has always been a bear to sequence, mostly because it’s virtually indistinguishable from its close relative, 5-methylcytosine (5mC) using classic bisulfite sequencing techniques. Now a new sample preparation method has hit the scene that can discriminate between cytosine, 5mC and 5hmC at single base resolution, called oxidative bisulfite sequencing (oxBS-Seq) that essentially smashes […]
Sequencing DNA Methylation Past, Present, Future with Dr. Wolf ReikApril 26, 2012Dr. Wolf Reik discusses the challenges in DNA methylation sequencing and the next big swings in epigenetic modification sequencing and discovery. This interview took place at the Keystone Symposia’s Epigenomics and Chromatin Dynamics joint meeting in January, 2012. This video was brought to you by epigenetics supporters at EMD Millipore. Sequencing DNA Methylation […]
Active Motif MeDIP-Seq Services Will Put You On the Right MethylPath™April 17, 2012Let’s say you want to get the ball rolling for studies on a new disease. You know you want to search for any important changes in methylation patterns; but with a whole genome worth of ground to cover, how do you decide where to look first? Active Motif now offers the MethylPath™ MeDIP-Seq Service that […]
Recorded NIH Webcast with Dr. Randy Jirtle: Epigenetics-How Genes and Environment InteractApril 17, 2012The interplay between epigenetics and the environment is one of many fascinating research areas of epigenetics. If you were lucky enough to attend Keystone Symposia’s Meeting on Environmental Epigenomics and Disease Susceptibility last spring, you were fortunate enough to hear from some of the world’s top researchers leading the way to a better understanding of […]
ChIP & Bisulfite-Seq Cut Through Chromatin, DNA Methylation ChatterApril 4, 2012There are two sides to every story. Maybe even more if you ask a lawyer. So it only makes sense that two epigenetic mechanisms like chromatin and DNA methylation would each have something to say about the genomic regions they regulate. Two new methods each combine ChIP and bisulfite sequencing in order to cut through […]