ENCODE and Roadmap Epigenomics Antibody Validation DatabaseJuly 19, 2011Many epigenetics techniques and projects rely on high-quality antibodies, but not all commercial antibodies perform well enough to get the job done. On top of that, there’s no uniform standard, or easy steps to fully validate a good antibody. With help of the Park lab at Harvard Medical School, there is now a place that […]
DNA Methylation Shifts in Early Immune DevelopmentJuly 19, 2011How can you know if something’s changed, if you didn’t see what it looked like to start with? That was the idea behind a new study that profiled DNA methylation in the immune development of youngsters. With more and more focus on environmental causes of immune diseases, and their epigenetic links, Australian researchers decided to […]
Different Strokes For DNA Methylation Patterns in Stem Cell LinesJuly 15, 2011Although we often think of human embryonic stem cell (hESC) lines as being pretty much the same (kind of like the Kardashian sisters), they really are different according to a report by UCLA researchers. Even though they usually can differentiate into the same cell types, hESCs have different methylation patterns—and that may affect gene expression. […]
Cancer Cells Keep Their Methylome Options OpenJuly 6, 2011As new research finds tumor cells don’t like to be tied to just one methylation pattern, they prefer a variety. In fact, that variation within tumors gives cells a big leg-up in challenging environments, and possibly even helps them avoid detection and treatment. Building on their earlier work on CpG shores and stochastic variation, the […]
EpiGenie Environmental Epigenetics ReviewJuly 6, 2011Thanks to growing interest from the general public, environmental epigenetics is a red-hot topic with no signs of cooling off anytime soon. We’ve certainly covered our fair share of research with an environmental slant to it, so if you want to review, research, or just plain get up to speed on the subject, these articles […]
