eBook: Aging and EpigeneticsJune 8, 2018This eBook explores various levels at which aging and epigenetics are related. Assembled are summaries of studies exploring specific questions regarding the epigenetic basis of aging and aging-related conditions. They are divided into four chapters: 1. DNA Methylation Epigenetic Clock 2. Anti-aging 3. Alzheimer’s Disease 4. Stem Cells
Keeping it CLASSY with RNA-directed DNA Methylation in ArabidopsisMay 22, 2018There’s many ways to keep it classy, and while the recent Royal Wedding has demonstrated that some families illustrate their style with an eclectic taste for hats and fascinators, the CLASSY family of chromatin remodeling factors has just out-classed them with its chromatin tastes that shape RNA-directed DNA methylation. In Arabidopsis thaliana, RNA Pol-IV triggers […]
Sea Snails Thank RNA-induced DNA Methylation for the Long-term Memories!May 16, 2018Forget everything you know about memories (!) because a new study has turned our knowledge regarding memory formation on its head by showing the ability to transfer memories from animal-to-animal! Current dogma states that learning-induced modifications of synaptic connections underlie the storage of our long-term memory (LTM); however, recent studies have suggested that neuron cell […]
Snord116 Keeps DNA Methylation’s Circadian Rhythm Ticking in the BrainMay 10, 2018Sunrise, Sunset. The tempo of a day can quickly pass us by while filling our brain with all epigenetics has to offer. But whether our brains are aware of it or not, with each sunrise and sunset comes a rhythmic genome-wide DNA methylation profile. To gain insight into exactly what makes our brain’s rhythmically tick, […]
Two Barcodes, One DNA Fragment: Budget-Friendly Single-Cell Whole-Genome Bisulfite SequencingApril 29, 2018While single-cell whole-genome bisulfite sequencing is rapidly evolving, the associated price tag hasn’t been quite as dynamic. This lack of dynamism is primarily because current single-cell whole-genome bisulfite sequencing (scWGBS) methods are limited by the need to process each cell in individual reaction vessels and also low alignment rates. These limitations mean a high (financial) […]