Guide: Bisulfite-Converted DNA AmplificationJanuary 12, 2015Over the years, bisulfite conversion has become the most widely used method for DNA methylation analysis. It is the most convenient and effective way to map DNA methylation to individual bases. As the first step in numerous downstream analysis techniques, it is absolutely critical that the bisulfite conversion process is understood and performed well. Our […]
Webinar: A Step-by-Step Guide to ChIP-Seq Data AnalysisJanuary 12, 2015In this webinar, Dr. Xi Chen takes publicly available real ChIP-seq data sets to show you how to perform ChIP-seq routine analysis using a combination of different online tools available. This provides an opportunity for bioinformatics beginners and wet-lab biologists who do not have much experience with unix operating systems to have an idea about […]
Uncovering Neural Differentiation Step-by-StepJanuary 9, 2015The Laetoli footprints made by humans 3.6 million years ago in Tanzania are perhaps the most famous footprints of all time. However, more recent footprints have been uncovered by the laboratories of Yechiel Elkabetz and Alexander Meissner. These epigenetic footprints represent each “step” in the process of neuronal differentiation from human embryonic stem cells (hESCs), […]
Smoking Damages the Epigenome for a LONG timeJanuary 8, 2015While we all know that smoking is bad for you, and even your baby, it seems that the effects last longer than you may think. Researchers from Imperial College London investigate and show that while there are epigenomic benefits to giving up smoking, there are also some changes that persist for what seems to be a lifetime. Previously, […]
Plotting the Path to Pluripotency Uncovers Key Role of DNA MethylationDecember 29, 2014If you’ve read our recent piece ‘Reprogramming Roadmap Reveals Fuzzy New Stem Cells‘ you’ll already know how “Project Grandiose” [1, 2], the brainchild of Andras Nagy, identified a new pluripotent state (the F-class stem cell). While the discovery of this new class is thrilling, the main purpose of this grand project was to uncover the […]
