Foretelling Future Hippocampal Transcription and Disease Risk with Early DNA Methylation ProfilesOctober 27, 2019Will it rain tomorrow? Will I ever win the lottery? Will our new paper finally be accepted!? Unfortunately, we have yet to come up with a sturdy means to predict our fates far in the future; however, new research by Hadad and colleagues now suggests that DNA methylation profiles in young cells accurately foretell changes […]
Studying TAD Boundary Issues Through Epigenome Editing of CTCF MotifsOctober 19, 2019So, your therapist says you have boundary issues? Well you’re not alone; CTCF is known to play a critical role in setting the boundaries of topologically associating domains (TADs), but there’s been no therapist to uncover their definitive impact. Thankfully, new research from the lab of Bradley Bernstein at the Harvard Medical School (Boston, USA) […]
A Perfect Harmony: Orchestrating Joint Chromatin Conformation and Methylome Mapping in Single CellsOctober 7, 2019If a better understanding of gene regulation is music to your ears, then tune in for the latest developments in single-cell epigenomics. It is well established that both DNA methylation and higher-order chromatin structure play crucial roles in development, differentiation and disease, and there are readily available technologies for both (whole-genome bisulfite sequencing and chromatin […]
Webinar: The Epigenetics of the Exposome and Aging – Paul G. ShielsOctober 2, 2019Don’t miss this great webinar detailing some of the latest discoveries about the role of epigenetics in aging. Aging results in a gradual and progressive loss of physiological functions and physical abilities over time. Overcoming the growing burden of age-related issues is one of the greatest challenges facing modern society. These issues are leading to […]
DNA Methylation Analysis Puts a Face to a Very Ancient NameOctober 1, 2019A long, long time ago, in a land far, far away (2014 at the Hebrew University of Jerusalem, Israel actually!) a team of researchers banded together under the leadership of Liran Carmel and David Gokhman. Rather than inventing the wheel or devising a strategy to capture wooly mammoth, the team developed a way to reconstruct […]
