Shifting Sex: Social Stress Throws Epigenetics in Reverse for Female Bluehead WrassesJuly 15, 2019Have you ever run into an unexpected detour on your commute? Whether it be an ice patch, flood, or even a mudslide, mother nature can reroute even the best laid plans, but for some species, changes in the environment have much higher stakes than being late for work or that much needed vacation. In fact, […]
eBook: NeuroepigeneticsJuly 4, 2019It’s become increasing clear that epigenetic mechanisms have a unique role to play in the brain. From neurodevelopment, to memory, to brain function epigenetic mechanisms seem to be very important. These mechanisms are also frequently perturbed in neurological disorders. In this ebook, we’ve assembled summaries of research related to uncovering the many roles of epigenetics […]
Mutant DNMT3A Underperforms in Overgrowth SyndromeJune 25, 2019If you’re underperforming at work, you might end up with a rejected paper, failed experiments, or an angry boss. However, this isn’t so bad when compared to how mutated DNMT3A underperforms in its role as a DNA methyltransferase, since that can result in a pathogenic overgrowth known as Tatton-Brown-Rahman syndrome (TBRS). Despite DNMT3A’s known role […]
Whole Genome Bisulfite Sequencing of Down Syndrome Brain Captures the Big PictureJune 18, 2019Sometimes in life, we get so focused on the details that we can miss the big picture. One of the best examples of this periscope perspective is the case of Down syndrome. Although it is caused by trisomy of chromosome 21, Down syndrome patients display genome-wide alterations to their transcriptomic and epigenomic profiles; however, the […]
Enhancer Hypomethylation in Alzheimer’s Disease Brain Paves the Way for Cell DeathJune 15, 2019When it comes to understanding the epigenetics of aging, Alzheimer’s Disease (AD) has enhanced our knowledge in countless ways. This neurodegenerative disease has taught us to embrace healthy aging, and some surprising players have emerged from the examination of DNA methylation. Studies have uncovered a role for enhancers in AD; however, investigations into the consequences of DNA methylation at these […]
