A Dynamic Epigenetic Editing Duo: Mutant DNMT3A and SunTag Team Up to Reduce Off-Target MethylationFebruary 4, 2020Some of the best superheroes are born out of a mutational event. It’s how Peter Parker became Spiderman, how Bruce Banner turned into the Incredible Hulk, and where the X-Men derive their powers. It just goes to show that mutations aren’t always a bad thing — a point exemplified by the new superhero team in […]
Single-cell Multi-omic Maps of Germ Layer Enhancers – Deciphering The Best-laid Body-Plans of Mice and Perhaps Men?January 22, 2020A weekend away with a book of poetry, a mountain biking holiday, or perhaps a daring jewel heist……whatever your idea of a fun weekend is, a well-laid out, precise set of instructions usually help; in short, you need a plan! In the gastrulating mouse embryo, precise epigenomic and transcriptomic instructions dictate the differentiation of pluripotent […]
Retrotransposons LIT the Way for Genomic Imprinting During EvolutionJanuary 9, 2020It’s clear that humans and mice have taken very different evolutionary paths, but new research suggests that transcription from long terminal repeat retrotransposons (LTRs), which are endogenous retroviral elements that can induce DNA methylation in oocytes, may have acted as guiding lights along the forks in the road. Besides the obvious differences in size, furriness, […]
The Epigenomics of Non-Coding DNA Variants with Dr. Guillaume BourqueDecember 20, 2019Dr. Guillaume Bourque from McGill University discusses his lab’s bioinformatic research examining the epigenomics of non-coding DNA sequence variants at the 2019 joint CEEHRC/IHEC meeting.
The Epigenetics of T-Cell Development with Dr. Ellen RothenbergDecember 20, 2019Dr. Ellen Rothenberg from the California Institute of Technology discusses her lab’s research into the epigenetics of T-cell development at the 2019 joint CEEHRC/IHEC meeting.
