Disrupted LADs Drive Epigenetic Alterations in Human Early-onset AgingJune 22, 2020The “driver” represents a crucial part of a successful Formula One team, a decent score at golf, and even a well-planned bank heist (!), and working out those factors that drive the onset of various diseases and disorders may provide critical mechanistic insight and even aid the development of novel therapeutic approaches. In the early-onset […]
Epigenetic Hole-in-One: Methylation of a Single CpG Disrupts GATA-1 Binding and Regulates Gene ExpressionJune 11, 2020The GATA-1 transcription factor is like the Tiger Woods of the erythroid cell lineage, topping the leaderboard and driving the expression of important developmental genes. Other molecular competitors, like the NuRD complex, are already on the course, but a new study shows how methylation of a single CpG is able to score a hole-in-one to […]
Dynamic Modeling of DNA Methylation “Turnover” Reveals Tasty Epigenetic MorselsJune 11, 2020While the word “turnover” may send the culinary-minded to the kitchen and the business-savvy straight to the accounts books, epigeneticists studying the turnover of DNA methylation have been left between a rock and a hard place! Researchers are in this unappetizing predicament as while we can accurately paint a genome-wide picture of DNA methylation levels, […]
A Rewired Metabolism Links the Aging Epigenome to Vision LossMay 16, 2020They say hindsight is 20/20, but for those of us looking over at a lifetime of memories, things might seem a little blurrier through our aging eyes. That’s because, unlike the fine wines, delectable whiskies, and smelly cheeses that we love to catabolize, the human epigenome tends not to age very well and a wide […]
Cannabis and Tobacco Produce a Double Hit on the EpigenomeMay 12, 2020While the epigenetic impacts of cannabis have been seen in sperm and adolescents, the effects on adults have not been well studied in large-scale studies. It’s commonly believed that smoking cannabis is less damaging than smoking tobacco; however, this is not backed by an abundance of actual data. Smoking tobacco is associated with numerous DNA […]
