Large Chromatin Domains Drive Pancreatic Cancer’s Sugar RushFebruary 14, 2017A sugar rush can fuel many things. It can power the late-night experiments demanded by reviewer number 3 or it can drive tumor evolution. Fueled by both these factors, new insight into the linked metabolic-epigenetic mechanisms of metastasis comes at you from a collaborative effort led by the lab of Andrew Feinberg in the Center […]
Copy Number Variation and Environmental Exposure Unwrap the DNA Methylation Storage Box of AutismDecember 29, 2016Preparing for a big event takes a lot of work; whether it be the holidays or developing a brain’s epigenome, keeping a storage box ready to go for the situation just makes sense. In their latest publication, the lab of Janine LaSalle at the University of California – Davis unwrap the epigenetic storage box of […]
dCas9-Dnmt3a-Dnmt3L Methyltransferase Seeds a Nuclear ReactionDecember 15, 2016Some scientific breakthroughs are so transformative that there’s no containing their spread once they’ve seeded. By engineering cellular nuclear reactions with a biochemical twist, the most powerful deactivated Cas9 (dCas9) methyltransferase explodes from the lab of Tomasz Jurkowski at the University of Stuttgart. The free energy of this reaction forges not only a new tool […]
Get Focused with MethylCheck™ Targeted DNA Methylation StudiesDecember 9, 2016Sure genome-wide DNA methylation studies steal a lot of the limelight, but often it’s targeted DNA methylation studies that handle all of that much-needed data validation, or those deeper dives into key methylated regions. That’s where targeted bisulfite sequencing shines. When you combine the reigning champ of DNA methylation analysis with next-generation sequencing, you get […]
Dnmt3C: A New Piece of DNA Methylation MachineryNovember 24, 2016A dog walk in the countryside led to Velcro, the search for chest pain therapies gave us (who me?) Viagra, and a messy microbiology lab bench provided penicillin. Some big research discoveries appear to have arrived in an “accidental” form and maybe, just maybe, new research from the laboratory of Déborah Bourc’his can be spoken […]
