A New Methylation Signature: CpG Ravines as a CpG Island Sub-TypeNovember 13, 2014Islands and shores are always on the mind at this time of the year, but just because winter is coming doesn’t mean we need to put the rest of the CpGenome on the shelf. CpG Shores might be the regulatory master of CpG Islands but new features keep emerging, like CpG Canyons, and now a new sub-type of CpG Islands is coming […]
In the Epitranscriptome Clusters of Co-Methylation Define m6A’s FunctionNovember 13, 2014Lately, at the EpiGenie HQ, we’ve had our mind on methylation and our money on RNA. Not just limited to DNA or Cytosine, we’ve seen that N6-methyladenosine (m6A) is a highly dynamic mark in RNA that has a critical role in stem cell differentiation. Now researchers from the Northwestern Polytechnical University in China have set out to find how m6A dynamics work on […]
in vivo CRISPR Takes Aim at Key DNA Methylation Players in the BrainOctober 31, 2014Adding to the ever growing potential of genome editing, one of the latest breakthroughs from the lab of Feng Zhang at the Broad Institute of MIT and Harvard puts CRISPR/Cas9 to the test with an interesting research trifecta of: in vivo genome editing focused on the brain genome editing that targeted DNA methylation machinery including key readers and writers. both […]
Developmental Origin of Schizophrenia-Associated DNA MethylationOctober 30, 2014Schizophrenia is one complex disease, with a number of subtypes and an origin unknown. However, despite it’s complexity, recent evidence points toward an interaction between genes and environment that are mediated by the epigenome. Further adding to the complexity is the fact that most patients are treated with powerful antipsychotics that also remodel the epigenome in […]
Natural Disasters Impact DNA MethylationOctober 16, 2014As Polar Vortex II approaches, you’ll be interested in a recent study highlighting the impact of environment stressors on the epigenome. Prenatal maternal stress exposure is known to adversely affect offspring in a number of ways, depending on the nature of the exposure, but is typically studied in common exposures like diet, alcohol, and lead. But this has left the […]
