Get Focused with MethylCheck™ Targeted DNA Methylation StudiesDecember 9, 2016Sure genome-wide DNA methylation studies steal a lot of the limelight, but often it’s targeted DNA methylation studies that handle all of that much-needed data validation, or those deeper dives into key methylated regions. That’s where targeted bisulfite sequencing shines. When you combine the reigning champ of DNA methylation analysis with next-generation sequencing, you get […]
Dnmt3C: A New Piece of DNA Methylation MachineryNovember 24, 2016A dog walk in the countryside led to Velcro, the search for chest pain therapies gave us (who me?) Viagra, and a messy microbiology lab bench provided penicillin. Some big research discoveries appear to have arrived in an “accidental” form and maybe, just maybe, new research from the laboratory of Déborah Bourc’his can be spoken […]
SALL4A Sets the Mood for a DNA Demethylation TET-á-TETNovember 16, 2016A romantic “tête-à-tête” between two lovebirds usually involves helping factors which set the mood and make the night move along slickly. A good wine, some soft lighting, and maybe even a little smooth jazz! While that might work for the humble researcher, the “TET-á-TET” involved in DNA demethylation is a slightly different affair and demands […]
Variation in CpG Methylation is Tied to Biological AgingOctober 19, 2016There aren’t many things in this world that we can be certain about, but aging marks an all too important exception. Towards the goal of understanding the marks of this unavoidable process, we’ve seen the epigenetic clock, which looks at CpG sites that are certainly differentially methylated as we age. However, a new perspective to […]
Meta-Analysis Reveals Grim Reaper is Keeping an Eye On Your Epigenetic ClockOctober 19, 2016They say ‘Seasons don’t fear the reaper’, and while the festivities of this season certainly favor the reaper, most of us dread the reaper’s favor. Our understanding of how to avoid that favor is now improving, thanks to some new insight from the epigenetic clock-watching lab of Steve Horvath at UCLA. The epigenetic clock consists […]
