Tuning Chromatin Microenvironments with Epigenome EditingAugust 27, 2016Ensuring the sustainability of our environment is a noble goal, and when it comes to the chromatin microenvironments epigenome editing is no exception. While we’ve seen a range of epigenome editing applications, the long-term (mitotically stable) nature of these modifications has remained a challenge. In 2002, epigenome editing demonstrated that when it comes to the […]
Maternal Diet And rDNA Variants Combine To Determine Child Epi-FateAugust 14, 2016If you’ve been following nutrition studies hoping for diet advice, you may have noticed it’s complicated. First fat is bad, then it’s just saturated fat, then just trans fat, then actually it’s sugar. This may cause some to throw their hands up in frustration (grabbing a Twinkie from the top shelf while they’re up there), […]
Extra-Coding RNAs (ecRNAs) Sculpt Dynamic DNA Methylation of the BrainJuly 18, 2016We’ve got our mind on methylation and methylation in our mind, but we are often left wondering how DNA methylation got there in the first place. Well, that cognitive tongue twister has now been cracked by a class of RNA that likes to interact with DNA methyltransferases. Extra coding RNAs (ecRNAs) originate from the sense […]
Hey Methylation, Thanks for the MemoriesJuly 18, 2016Memories; we all have some we would rather forget, and some that we will hold onto forever. But how exactly is memory formed and what are the biochemical pathways that are in play? Recent studies have indicated that RNA and DNA adenosine methylation are important for the conversion of experiences, both good and bad, into […]
scAba-seq: Single-Cell, Genome-Wide, and Strand-Specific 5hmC SequencingJuly 6, 2016Usually, you don’t want your genome sequencing served up with a sugar coating; however, thanks to a clever a new 5hmC sequencing technique, we can indulge in some sweet single-cell and strand-specific insight. The study of 5hmC (5-Hydroxymethylcytosine) prevalence in DNA typically involves utilizing modified bisulfite sequencing, 5hmC specific antibodies, or restriction enzymes. Aba-seq makes […]
