Metformin Keeps Aging Primate Epigenomes “In Form”September 30, 2024Those of us feeling the all too familiar effects of time may look to cut back on certain “excesses” and keep fit (in both body and mind) to maintain a healthy aging process. Now, a team of fitness enthusiasts has revealed that long-term treatment with the diabetes drug metformin maintains an aging population of monkeys […]
scEpiAge Brings Single-cell Resolution to Epigenetic Clock HeterogeneitySeptember 23, 2024DNA methylation-based epigenetic clock construction has generally relied on bulk datasets representing findings from thousands or millions of cells, and now, a new single-cell epigenetic clock age predictor known as scEpiAge may help to resolve the impact of heterogeneity. Can improved resolution offer more profound insight into the aging process? A team led by Marc […]
Genome-Wide DNA Methylation Changes from Vaping and Smoking Have Striking SimilaritiesSeptember 3, 2024Vaping has been touted as a safer alternative to smoking, but some recent studies are showing that the biological effects have similarities. Now, a team clears the air and reports that DNA methylation changes in vapers’ oral cells resemble those found in smokers, which suggests that vaping could have comparable long-term health effects. Smoke gets in […]
Keeping up With Epigenetic Clocks: PRC2-AgeIndex Measures Gains of DNA Methylation Across the GenomeAugust 6, 2024While it may seem like it’s harder to keep up with epigenetic clocks than with the Kardashians, this is one you’re not going to want to miss. Many epigenetic clocks people use to assess aging are built on the DNA methylation status of a few CpGs, and it’s unclear how these sites are related to […]
CoRSIVs in Cows? Targeting a DNA Methylation Bullseye May Improve Livestock Farming!August 5, 2024Finding informative epigenetic targets in the genome is no easy task; however, cleverly composed studies previously reported on the discovery of correlated regions of systemic interindividual variation (or CoRSIVs) in humans – DNA methylation patterns that vary between individuals but remain consistent across tissues. Now, this talented team sets its sights on understanding this level […]
