Taking “CoRSIV” Writing from Short Notes to “Novel” Epigenetic Findings in Disease RiskJanuary 30, 2023Previously, a perfectly-penned study uncovered a type of DNA methylation variation “written” in the genome, which varies from person to person but remains consistent across tissues. Deciphering these “CoRSIV” (correlated regions of systemic interindividual variation) notes supported a deeper understanding of epigenetic variance and the impact on disease, with blood DNA methylation profiles from these […]
scChIX-seq Brings Double the Fun to Single-Cell Histone Modification ProfilingJanuary 23, 2023How do you double your fun? An extra scoop of ice cream, coffee and a cake, or the epigenetic delights of single-cell profiling of not one but two histone modifications? In the latter case, the scChIX-seq (single-cell chromatin immunocleavage and unmixing sequencing) integrated framework may represent a wise choice for those looking to indulge while […]
Chromatin-Con 2023: Epigenetics of Aging Online ConferenceJanuary 19, 2023Our friends and colleagues at Active Motif will be hosting an online conference focusing on the epigenetics of aging. Tune in if you can…Just take a look at the list of speakers and we’re sure you won’t want to miss it! Click over to the Active Motif website for more details and to register: Chromatin-Con […]
eBook: Epigenetics of AgingJanuary 16, 2023Aging and longevity research has moved to the forefront of epigenetics in recent years. From DNA Methylation, to the Exposome and “translational inheritance” we are all avidly interested in this topic. In this eBook we review recent and intriguing research into this topic. Table of Contents Novel Multiomic Epigenetic Clock May Decipher How Epigenetic Aging […]
Active DNA Demethylation as a Source of DNA Damage at EnhancersJanuary 3, 2023Paint a self-portrait, build a house? If, instead, your more achievable New Year’s resolution was to be more active, new and exciting findings on how the abundance of single-strand DNA breaks (SSBs) at neuronal enhancers represents an intermediate of active DNA demethylation will be right down your alley! Researchers led by Wei Wu and André […]
Can Engineering Chromodomains Take Histone Methylation to “Affinity” and Beyond!?December 4, 2022The troupe of “toys” we use to explore the world of histone methylation just gained a new friend thanks to a playful team of epigenetic engineers who have taken histone modification-reading chromodomains to “affinity” and beyond! Researchers led by Gianluca Veggiani (Louisiana State University, USA) and Sachdev Sidhu (University of Waterloo, Canada) knew that histone-modification […]
eBook: Epigenetics & DNA MethylationNovember 21, 2022One of the longest-known and most studied epigenetic markers is DNA methylation, which can regulate gene expression and genomic organization in nearly all organisms. In eukaryotes, the primary modification of DNA is found in cytosines (C), where DNA Methyltransferases mediate the transfer of a methyl group to cytosines, converting them to 5-methylcytosine (5-mC), minor modifications […]
An Inflammatory Microclimate Seeds a Super-enhancer That Drives TumorigenesisNovember 7, 2022While microclimates shape environments along coastlines and urban jungles, this phenomenon isn’t restricted to macroscopic landscapes; now, a new study provides evidence that inflammatory signaling from the tumor microenvironment (TME) alters the epigenetic landscape by inducing the formation of a super-enhancer (SE) that drives tumorigenesis. An environmentally-friendly team led by Ramon E. Parsons (Icahn School […]
An Eerie Epigenetic Disguise Helps SARS-CoV-2 Avoid Anti-viral ResponsesOctober 25, 2022Every avid trick-or-treater aspires to have the perfect Halloween costume; now, a spooky study has revealed how an unwanted guest – SARS-CoV-2 – dons an epigenetic disguise to help this virus trick its way past host defenses to infect human cells! A fearless team led by Erica Korb (University of Pennsylvania, USA) knew that SARS-CoV-2 […]
RT&Tag Maps the Fleeting World of Chromatin-associated RNAsOctober 25, 2022Between the vast lands of DNA and proteins lies the ephemeral and dynamic world of chromatin-associated RNAs, a less-explored but utterly critical domain of the eukaryotic nucleus. Thankfully, RNA-focused researchers can now turn to a tagmentation-based profiling technique (“RT&Tag”) to map the landscape of regulatory chromatin-associated RNAs to aid this quest. In their fascinating study, […]