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Ever get that feeling that you forgot something? Well maybe you did, but it doesn't have to be recent epigenetics research if you scope out our Headlines each week.

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mRNA Alternative Polyadenylation Lifestyles Comes into Focus

January 17, 2013

As the only epigenetics media group based out of southern California, we’ve learned to be very accepting of alternative lifestyles, which is why this method caught our eye. mRNA are a diverse bunch, with all kinds of alternative polyadenylation that can affect their cellular localization and stability. RNA Seq has enabled unprecedented glimpses into the transcriptome, but […]

Making Sense of the Grade: ChIP Validation Terminology

January 17, 2013

Antibody vendors have been hard at work to offer antibodies that are suitable for applications like ChIP. Usually these antibodies have been used successfully in peer-reviewed publications. In many cases they’ve been validated internally by an R&D team, and in some cases, each lot may be validated to work in ChIP applications. The tricky part […]

MeCP2 Puts 5hmC in a Bind in Active Neuronal Genes

January 7, 2013

A good actor can play very different roles and still make you believe in the character. For example, who knew Wolverine could emote and sing, like Hugh Jackman does in Les Misérables? Just the same, it turns out that MeCP2, a protein thought to repress transcription by binding to 5mC (5-methylcytosine, actually seems to encourage […]

DANPOS Reveals Dynamic Nucleosomes

January 2, 2013

Keeping track of where some nucleosomes are on chromatin can be just as tricky as keeping track of Taylor Swift’s love life. They’re on, they’re off, they’re at a new place. Well, here comes a new bioinformatics solution to help you keep score on the nucleosome front, anyway. It’s called DANPOS, and it provides single-nucleotide […]

Watch Chromatin “Breathe” in Embryonic Stem Cells

December 31, 2012

This holiday season, we breathed in lots of good smells—the scent of pine trees, the aroma of pumpkin pie, and the unmistakable smoky smell of a roaring fire. Now, researchers say they’ve caught chromatin in the act of “breathing” in human embryonic stem cells (hESCs) before they differentiate. The team from California and Italy developed […]

Top Epigenetics & ncRNA Conference Picks for Winter 2013

December 27, 2012

We’re on the verge of 2013. For those of you who want to up your epigenetics research game and have some fun in the process, we’ve got conferences you should definitely check out. The year starts off a little quiet on the numbers front, but the quality more than makes up for it. January […]

EMdeCODE Deciphers Epigenetic Code, Finds New Role for Old Histone Modifications

December 19, 2012

With all the “LOL”s, “IMHO”s, and “YOLO”s out there, it’s like we’re all speaking in code. When we get stumped on what these things mean, we can always turn to Google. But what if you want to decipher the hypothetical “epigenetic code?” Well, one researcher has the answer—EMdeCODE, a new algorithm that does just that […]

Hypermethylation in miRNA 26a Provides New Route in Prostate Cancer Progression

December 12, 2012

There’s usually more than one right way to get where you want to go. Unless of course, you’re using Apple Maps, then all routes are questionable, but at least have a pretty interface. It turns out there are at least two ways to wind up with prostate cancer, and neither are that attractive—having a gene […]

New and Improved: Multiplexed Reduced Representation Bisulfite Sequencing (RRBS)

December 7, 2012

These days, we’re all about multi-tasking—talking on our cell phones while placing our cappuccino order at Starbucks and tweeting about it all on our tablets. In that same vein, researchers report an optimized protocol for multi-tasking (well, technically “multiplexing”) reduced representation bisulfite sequencing (RRBS) for ramped-up DNA methylation data. RRBS is great, churning out methylation […]

The Daily Rhythms of Transcription and the Epigenome

December 7, 2012

We all have a daily routine. For much of the EpiGenie office staff, that includes getting out of bed, brushing our teeth, going to work, grabbing a coffee, clocking a few hours on Facebook and complaining that there aren’t enough hours in the day. Now, researchers say that transcription and epigenetic modifications in mouse liver […]