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Epigenetic “Baby-steps” Repress Germline Genome-defense During Development

February 4, 2022

Much like a set of helping hands can guide, support, and protect a toddler taking their first steps, the guiding force of epigenetics during embryonic development ensures genome stability and supports healthy development by regulating the expression of key genes. Such genes include DNA methylation-sensitive “germline genome-defense” genes, which undergo DNA demethylation and become expressed […]

Want to Navigate the Epigenomics of Disease Across 3,604 Studies? There’s An App For That

February 1, 2022

Traveling through large cities is complicated. Thankfully, our apps help us find a way through the maze and lead us to our destination. Now, a new method has come forward to do the same for the epigenomics of disease. A group led by Charles Breeze and Sonja Berndt (National Cancer Institute) have developed a program that guides […]

Down the Wrong Path: Trisomy 21 Pushes Neural Progenitors Towards Senescence Profile

January 31, 2022

Although it sometimes feels like there is no right way to age, intriguing insight from Down Syndrome has given insight into how disrupted nuclear architecture can push us down the wrong path. Down syndrome results from the triplication of chromosome 21 and is a leading cause of intellectual disability. However, Down syndrome is also a […]

Like a RedChIP to a Bull! – New Technique Explores RNA-Protein-DNA Interactions

January 30, 2022

The publication of a new technique is like waving a red rag to a bull for many in the epigenetics arena. Now, “RedChIP” has us stampeding in anticipation towards the exploration of the complex interactions taking place between RNA, DNA, and proteins in the nucleus. Olé! Non-coding RNAs (ncRNAs) interact with proteins and DNA to […]

Architectural Woes Prompt Age-related Problems Thanks to Genes Lacking CpG Islands

January 20, 2022

As cracks to walls and beams can lead to an old house coming apart at the seams, the architectural alterations associated within an aging nucleus can prompt degenerative processes at the cell and tissue level. While any good architect can identify and help to sure up the problematic elements bringing down the house, the blueprints […]

scAge – A Single-cell DNA Methylation Clock Details Epigenetic Aging and Rejuvenation

January 10, 2022

With the new year comes a fresh start, but does the aging epigenome of each one of our cells share this sentiment? To help get your new year off to the right start, a new program known as “scAge” allows the determination of the age of single cells via DNA methylation and reveals insight into […]

A Youthful Brain Boost via DNA Hydroxymethylation: TET1 Enters the Myelin Repair Technician’s Toolkit

December 13, 2021

Does it feel like your aging brain cells have been firing a little slower lately? Why not refresh your connection and speed up your synaptic signal transmission with a visit from your oligodendrocyte myelin repair technicians. Their youthful TET1 and DNA hydroxymethylation repair kit will bring you back to fiber-optic speeds in no time. This […]

A Circulating microRNA Makes a Macro Difference in the Battle Against COVID-19

November 28, 2021

From holding the door open to passing on a link to an exciting epigenetics paper – small gestures can make an enormous difference to anyone’s day! Now, an exciting new study suggests that the expression of a microRNA has a macro impact during SARS-CoV-2 infection and could represent an important target for the treatment of […]

Automated Chromatin Profiling Platforms Autopilot Patients to the Clinic

November 22, 2021

From human-free supermarket check-outs to autopiloted cars, the modern world is rapidly moving towards automation. In the most recent advance, a rabble of robotic researchers has applied related technological tricks to epigenetic assays to “autopilot” high-throughput chromatin profiling and provide a clinical tool that may support optimized treatment choices in leukemia patients. Specifically, a technology-driven […]

dCas9 Hinders DNA Methylation to Cast Off the Confounds from Causality

November 4, 2021

Our day-to-day experiences provide a clear understanding of cause-and-effect; a lab mate’s birthday means cake for lunch, and cake for lunch means hours of hard work in the gym! While this cake-centric concept might be simple and easy to follow, the seemingly straightforward causal relationship between DNA demethylation and the upregulation of gene expression, much […]