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Ever get that feeling that you forgot something? Well maybe you did, but it doesn't have to be recent epigenetics research if you scope out our Headlines each week.

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EpiGenie Guide: Chromatin Shearing

March 6, 2020

ChIP-Seq has transformed the field of epigenetics, providing unprecedented resolution and coverage for surveying protein- DNA interactions. Powerful, high-throughput sequencing is credited with most of the benefits, but there’s a lot more that goes into ChIP-Seq than sequencing. Chromatin shearing is one of the first critical steps in the ChIP-Seq workflow. Depending on your approach, […]

dCas9-ROS1 Cuts Out the Methylation Middlemen in Targeted DNA Demethylation

March 3, 2020

As the saying goes, the shortest path from A to B is a straight line and if you’re studying DNA demethylation, you know just how complicated things can get along the road from methylated to unmethylated cytosines. Mammals use Ten-Eleven Translocation proteins (TET) to oxidize 5mC, but the process creates pit stops that may be […]

Epigenetic Study Suggests that the Safety of Vaping is Running on Fumes

March 2, 2020

With as many flavors as there are epigenetic modifications, vaping has arrived on the scene as a safer alternative to the smoking of cigarettes and a means to give up a rather unhealthy habit. However, the rise in vaping-related lung injuries and the “unforeseen” massive uptake of vaping by teenagers have prompted scientists to undertake […]

Inactive X Chromosomes SPENd Time Tucked Under the Epigenetic Covers

February 25, 2020

When it’s the dead of winter, and the world outside is frozen solid, there’s no better place to be than under a mountain of warm blankets, like an inactivated X chromosome under a cloud of Xist long-noncoding RNA. Although we’ve known for a while that Xist is necessary for X chromosome inactivation (XCI), the mechanisms […]

ATAC-Me: An Epigenetic One-Two Combo Hits the Mark at Enhancers

February 16, 2020

There are many ways to “attack” a problem – head-on, from the side, with great care, or swiftly and suddenly, but as many a boxer may tell you, the classic one-two combo usually works a treat. Now, in a slugfest of a new study, a rambunctious rabble of ring-ready researchers recently hit the mark and […]

A Novel lncRNA Plays Cat and MAOs with Aggressive Behaviors

February 4, 2020

It’s the classic dilemma — do you eat that delectable morsel of cheese now or save it for later? If you tend to lack self-control, you might be at higher risk of impulsive or aggressive behavioral disorders, which have been linked to genes in the monoamine oxidase (MAO) family. A new study from the lab […]

A Dynamic Epigenetic Editing Duo: Mutant DNMT3A and SunTag Team Up to Reduce Off-Target Methylation

February 4, 2020

Some of the best superheroes are born out of a mutational event. It’s how Peter Parker became Spiderman, how Bruce Banner turned into the Incredible Hulk, and where the X-Men derive their powers. It just goes to show that mutations aren’t always a bad thing — a point exemplified by the new superhero team in […]

N6-methyladenosine-modified CarRNAs Hit the Epigenetic Brake on Transcription

February 3, 2020

Nitrous systems, improved aerodynamics, and slick tires on your car may all help to quench your need for speed when you get behind the wheel; however, the need to slow down is just as critical in the world of gene regulation. Recently, a team of researchers has described how the modification of a racy subset […]

Single-cell Multi-omic Maps of Germ Layer Enhancers – Deciphering The Best-laid Body-Plans of Mice and Perhaps Men?

January 22, 2020

A weekend away with a book of poetry, a mountain biking holiday, or perhaps a daring jewel heist……whatever your idea of a fun weekend is, a well-laid out, precise set of instructions usually help; in short, you need a plan! In the gastrulating mouse embryo, precise epigenomic and transcriptomic instructions dictate the differentiation of pluripotent […]

Epigenetic Editing Makes the (Neuronal) Connection Between C11orf46 and Neurodevelopment

January 21, 2020

Whether it’s our personal of professional lives, we’re told time and time again that making the right connection is key. It turns out that that’s also true for our brains; making proper neuronal connections early is make or break. Altered neuronal connections can cause neurodevelopmental disorders. Often, these disorders are associated with mutations in genes […]