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A Dynamic Epigenetic Editing Duo: Mutant DNMT3A and SunTag Team Up to Reduce Off-Target Methylation

February 4, 2020

Some of the best superheroes are born out of a mutational event. It’s how Peter Parker became Spiderman, how Bruce Banner turned into the Incredible Hulk, and where the X-Men derive their powers. It just goes to show that mutations aren’t always a bad thing — a point exemplified by the new superhero team in […]

N6-methyladenosine-modified CarRNAs Hit the Epigenetic Brake on Transcription

February 3, 2020

Nitrous systems, improved aerodynamics, and slick tires on your car may all help to quench your need for speed when you get behind the wheel; however, the need to slow down is just as critical in the world of gene regulation. Recently, a team of researchers has described how the modification of a racy subset […]

Single-cell Multi-omic Maps of Germ Layer Enhancers – Deciphering The Best-laid Body-Plans of Mice and Perhaps Men?

January 22, 2020

A weekend away with a book of poetry, a mountain biking holiday, or perhaps a daring jewel heist……whatever your idea of a fun weekend is, a well-laid out, precise set of instructions usually help; in short, you need a plan! In the gastrulating mouse embryo, precise epigenomic and transcriptomic instructions dictate the differentiation of pluripotent […]

Epigenetic Editing Makes the (Neuronal) Connection Between C11orf46 and Neurodevelopment

January 21, 2020

Whether it’s our personal of professional lives, we’re told time and time again that making the right connection is key. It turns out that that’s also true for our brains; making proper neuronal connections early is make or break. Altered neuronal connections can cause neurodevelopmental disorders. Often, these disorders are associated with mutations in genes […]

Retrotransposons LIT the Way for Genomic Imprinting During Evolution

January 9, 2020

It’s clear that humans and mice have taken very different evolutionary paths, but new research suggests that transcription from long terminal repeat retrotransposons (LTRs), which are endogenous retroviral elements that can induce DNA methylation in oocytes, may have acted as guiding lights along the forks in the road. Besides the obvious differences in size, furriness, […]