Fetal Stress: The Imprinting of GenerationsAugust 13, 2013Stress gets to us all on occasion. Whether it’s the more familiar stress that leads to hair-tearing-out, or some other version like coping with a bully, plants dealing with temperature changes, or even alcohol exposure as a fetus, stress has been shown to have profound effects on individuals down to an epigenetic level. But as […]
RRBS Dives Deep into Zebrafish Brain MethylomesAugust 12, 2013Get ready for the Zebrafishnado! OK, a tornado filled with cute little aquarium fish isn’t nearly as terrifying as a Sharknado, but a whirlwind of new data on zebrafish methylomes did reveal that their DNA methylation patterns are pretty unique compared to other species, including humans. Scientists from New Zealand realized that no one had […]
DNA Methylation Adds Variety to Human PopulationsAugust 7, 2013If variety is the spice of life, then DNA methylation sure seems to be supplying some of the flavor. A new study shows that DNA methylation isn’t just responsible for the differences in individuals, but for variations in populations as well. We’re no strangers to the way that DNA methylation can differ in diseases and […]
Epigenetics goes Viral: Herpes the Histone HijackerJuly 25, 2013By the age of 40 most of us will be infected with human cytomegalovirus (hCMV), which is a human herpes virus. Pretty scary, eh? But fear not, hCMV infections are usually harmless. However, it still posses a significant public health risk as the virus remains the leading infectious cause of birth defects and a serious […]
CRISPRi: The User-Friendly Transcriptional RepressorJuly 25, 2013Usually when you think of the immune system it isn’t at the level of our bacterial friends. But “prokaryotes have evolved diverse RNA-mediated systems that use short CRISPR RNAs (crRNAs) and Cas (CRISPR-associated) proteins to detect and defend against invading DNA elements” This system, also known as the CRISPR/Cas system, is a prokaryotic immune system […]
Vitamin C in Media Critical for ES Cell 5hmCJuly 24, 2013Whether its pop culture (like the ongoing royal baby mania) or cell culture, there’s no denying the enormous impact that ‘media’ has on our life. In fact, new evidence shows that a little Vitamin C in cell culture media can influence mouse embryonic stem (ES) cells, like typical pre-teens, to undergo a blastocyst-like identity crisis. […]
Placental miRNAs Predict Infant BehaviorJuly 18, 2013Many parents consider their children’s behavior to be a bit of a mystery, (just ask anyone who has shared a plane ride with an unruly toddler) but new miRNA research hints that it may soon be possible to predict your child’s behavioral traits by a simple non-invasive test right after birth. A fortune telling team […]
Disrupting DMNT1’s Cancerous InteractionsJuly 9, 2013It seems like almost every gene examined today has it roots in cancer, and epigenetic mechanisms haven’t missed the invite to that party. But with all these players comes an overwhelming heterogeneity that has troubled researchers looking for a cure ever since cancer was described as an epigenetic disease. Some research groups have tried out […]
Turn by Turn Navigation of DNA Methylation Maps in the Human Brain Now AvailableJuly 9, 2013Whoever claims cartography is a lost art hasn’t visited the Salk Institute lately. The cliffside research palace in La Jolla is home to a number of ambitious researchers who’ve been busy the last few years mapping every nook and cranny of the epigenome. Most recently, a team of clever researchers led the charge on mapping “genome-wide composition, […]
It’s a Histone-Regulate-Histone World Out ThereJuly 9, 2013The central dogma has taken quite a beating thanks to epigenetics rule-bending ways. With all the cross talk and looping going on it’s hard to tell who’s the boss these days. In their recent review, Mahajan and Mahajan from the Moffit Cancer Centre in Florida discuss the implications of their latest finding (Nature Structural & […]