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BrdU Kicks Out DNA Methylation and Kicks Off Stem Cell Differentiation

March 7, 2012

For many things in life, convenience comes at a cost. Like living in a great city with everything at your doorstep, but the rents are sky-high. A new report says that the use of BrdU, a popular tool for detecting replicating cells (such as neural stem cells in the brain), also comes with a cost, […]

Epigenetics at the Intersection of Environment and Selection

February 28, 2012

One of the most fascinating things about epigenetics is the implication it has for inheritance and evolution. Theories and hypotheses are everywhere, of course, but until Sir Richard Branson launches a Virgin Time Travel business, actually measuring the changes from thousands of years of natural selection will remain a pretty tall order. Two recent papers […]

The New Human Epigenome Browser from WashU

February 23, 2012

Looking for the latest in epigenome data analysis tools? Then you’ll want to check out Washington University’s latest creation; The Human Epigenome Browser. Built as part of the Roadmap Epigenomics Project to house and view Human Epigenome Atlas data, this new platform comes with all sorts of slick features to make analyzing, comparing and integrating […]

So Emotional: HDAC6 Affects Mouse Behavior

February 22, 2012

We all have bad days every so often and if you’re like us, you chalk up that depression or anxiety to something like, a looming project deadline or insufficient sleep and caffeine. A new study though, shows that there might be an unlikely culprit behind those negative emotions, your histone deacetylase 6 (HDAC6) levels. Acetylation […]

Emerging Details On Monoallelic Silencing in Tumors

February 19, 2012

It’s funny how research can pay off in surprising ways. In this case, University of Wisconsin scientists were studying the tumor suppressor gene APC when they realized there was an unusual brand of monoallelic silencing going on. Earlier studies have found that many early adenomas begin with the loss of function of the Adenomatous polyposis […]

Cells Socialize via miRNAs to Protect Against Atherosclerosis

February 16, 2012

Nowadays, there are ton of ways to talk to your friends—phone, text, email, Facebook, Twitter, Skype…Now, an international team of researchers add to the growing literature showing that cells can talk to each other by sending out vesicles with miRNAs in them. This time, the cells are inside blood vessels, and the message is to […]

Epigenetics and Twins

February 8, 2012

Every summer outside Cleveland, Ohio identical twins congregate at the Twins Days Festival. Twins from all over join in on an assortment of activities over three days that resembles a massive Doublemint® gum commercial. It’s not just the twins that get stoked for the festival though. As was highlighted in a nice article in National […]

Big DNA Methylation Changes in Little Tikes

February 7, 2012

Kids grow and change so fast. One day, they’re learning to walk. The next day, they’re Twittering and texting while driving your car. In the first study to analyze age-related DNA methylation (DNAm) changes in pediatric blood samples, an all-star cast of researchers out of Emory University now report that DNAm changes more rapidly during […]

Assisted Reproduction Treatments May Cause Imprinting Problems

January 26, 2012

These days, there is more than one way to make a baby. Unfortunately though, the newer ways still don’t have things down to a science yet. Assisted reproduction treatments (or technology, known as ART) are clinical procedures designed to help patients with fertility issues get pregnant. But reports have documented a rise in cases of […]

5-hmC Stability a Mixed Bag in Neural Development and Aging

January 25, 2012

Just like tweets about the U.S. Presidential race, updates on the function of 5-hydroxymethylcytosine (5-hmC) keep pouring in. For a while, no one really knew what the mod did, but new reports find that while some 5-hmC marks are stable, and others are dynamic, both may be critical for neural development right after birth and […]