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HiRES Lets You See Chromatin Structure and Transcription Clearly—At the Same Time

July 10, 2023

To see clearly, sometimes you just need a good pair of glasses or contacts. Now, Dong Xing’s lab (Peking University) has combined single cell Hi-C and RNA-seq to get a “Hi-RES” picture of chromatin and gene expression from the same cells simultaneously. Sure, separate Hi-C and RNA-seq data from different cells have been combined before, but […]

Dnmt3bas Is Inactive Dnmt3b’s Nemesis, Keeping Its Levels Low via Transcription and Splicing

July 10, 2023

The main character of many movies has a memorable nemesis who can’t help but try to bring them down and get in their way. Now, it turns out that the nemesis of the inactive Dntm3b isoform may just be development’s best friend. Before differentiation, Dnmt3b transcript levels are kept low, but get a boost at differentiation. […]

DNA Methylation Alterations Highlight Drivers of Aggressive Metastatic Tumors

July 3, 2023

The identification and early detection of events driving the metastasis of primary tumors may help identify therapeutic targets and patients that respond to specific therapeutics. Now, an epigenetic study focused on the spread of colorectal cancer to the liver reports DNA methylation as the spark driving metastatic events. Roadworthy researchers led by Euan J. Rodger, […]

Single-cell Epitranscriptomic Mapping of m6A from Small Samples with picoMeRIP-seq

July 2, 2023

Most successful epitranscriptomics studies rely on large amounts of input sample; however, huge findings may also reside in the smallest of specimens, such as zygotes or embryos. Now, a study provides exciting in vivo insight into these microcosms by describing the development of an epitranscriptomic mapping technique for single-cells and rare cell types. While traditional […]

X Chromosome vs. Autosome – m6A Helps to Level the RNA Stability Playing Field

June 26, 2023

While the single transcripts from the X chromosome may have a tough time competing with the one-two combination from their autosomal counterparts, heavy-hitting new findings now demonstrate that the m6A RNA modification lends a hand and levels the RNA stability playing field. The N6-methyladenosine RNA modification (m6A) recruits YTHDF proteins to reduce modified RNA stability […]

eBook: Chromatin & Gene Expression

June 14, 2023

Gene expression is regulated by a range of factors, but ultimately begins with chromatin – it’s structure, configuration, activation, and “openness”. All of these factors can be dynamically regulated by epigenetics. In this eBook, we bring to your attention some of the most interesting articles in chromatin biology and gene expression, from practical methods to […]

Single-Molecule Methylation Profiles of Cell-Free Cancer DNA—Without Playing Games

June 14, 2023

Sometimes, you have to jump through a lot of hoops to get what you want. Hanlee Ji’s lab (Stanford) must be tired of playing those games because they’ve developed a direct single-molecule methylation nanopore sequencing approach for cell-free DNA (cfDNA) that doesn’t involve bisulfite conversion or even PCR. And yet it works on nanogram or […]

Copper Controls the Epigenetic Regulation of Inflammation? Element-ary, my Dear Watson!

June 13, 2023

While some problems simply need a Deerstalker and a helpful sidekick to solve, discovering the cellular processes controlling inflammation has been less of an “element-ary” task! Now, an epigenetic study (in Scarlet?) links inflammation to a mechanism involving a membrane protein, the uptake of copper, and histone modifications in macrophages! A team of epigenetic investigators […]

Move Over Caloric Restriction – Hungry-Hungry Histones Slow Aging!

May 30, 2023

Kick the kebab, bin the burger, axe the avocado toast?! While caloric restriction represents a hunger-inducing yet effective means to extend lifespans, a tasty new study highlights how “hungry-hungry histones” create a neural hunger “state” that slows aging (even when getting our fill), suggesting that growing old may be more delicious than we think! While […]

Gene Topology or Gene Expression? NSD1 Chooses Both to Protect the Brain

May 23, 2023

We have to make a lot of decisions in our lives, but sometimes when given two choices, going with both can be the right answer. For example, researchers working on neurodevelopment figured out two different phenomena that regulate non-CG methylation in the postnatal brain, but how are they connected? Now, Harrison Gabel’s lab (Washington University […]

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