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Ever get that feeling that you forgot something? Well maybe you did, but it doesn't have to be recent epigenetics research if you scope out our Headlines each week.

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Argonaute AGO2 Gives miRNAs a Little Trim Around the Edges

April 17, 2012

Isn’t there always one person in a group of friends who’s a little weird or different? It turns out that AGO2, is a little different from its Argonaute paralogs, AGO1, 3, and 4. Researchers in Singapore are reporting that unlike other Argonautes, oddball AGO2 trims mammalian miRNAs, changing their functions during development. The team knew […]

miRNAs Decide Which Honey Bees Do Which Honey-Do’s

April 17, 2012

It seems nobody has been busier than the honey bee lately when it comes to being a model epigenetic organism. (Watch your back c. elegans!) Over the last year or so, we’ve seen how HDAC inhibitors affect the bee caste system, as well as how social cues alter DNA methylation patterns in the brains of […]

Recorded NIH Webcast with Dr. Randy Jirtle: Epigenetics-How Genes and Environment Interact

April 17, 2012

The interplay between epigenetics and the environment is one of many fascinating research areas of epigenetics. If you were lucky enough to attend Keystone Symposia’s Meeting on Environmental Epigenomics and Disease Susceptibility last spring, you were fortunate enough to hear from some of the world’s top researchers leading the way to a better understanding of […]

Colon Cancer Signs on the Dotted Line with Epigenomic Enhancer Signature

April 16, 2012

Handwriting experts say that someone’s signature reveals a lot about their personality. Whether these analyses are “scientific” is debatable, but researchers in Ohio and New Hampshire have evidence that they’ve identified a signature of enhancer histone modifications that points to colon cancer. Mono- and dimethylated H3K4 marks many classes of enhancers, so the team did […]

Schizophrenia’s DNA Methylation Fingerprints

April 4, 2012

By now, we’re all used to hearing about epigenetics in cancer or stem cell research, but its role in mental illness is still a pretty new concept. Understanding how exactly DNA methylation factors into schizophrenia may be a ways off, but new research promises to soon be able diagnose the condition through just a blood […]

Timeline for DNA Methylation in Mouse Development

April 4, 2012

Not everyone is onboard with the new Facebook timeline, but here’s a timeline you can really get into. Researchers are reporting the first genome-scale, base-resolution timeline of DNA methylation in the mouse embryo, including an analysis of the DNA methylation of oocytes and sperm. To do this, the team analyzed mouse oocytes, sperm, zygotes, early […]

Webinar: Uncover Epigenetic Signatures Faster using SureSelectXT Human Methyl-Seq

April 3, 2012

Agilent Technologies presented a Webinar back in March titled: Uncover Epigenetic Signatures Faster using SureSelectXT Human Methyl-Seq SureSelect is the most complete, flexible and proven Target Enrichment platform for Next Generation Sequencing. This presentation highlights features of the new SureSelect SureSelectXT Human Methyl-Seq kit including: • Reduced bias compared to existing Methylation methods • Comprehensive […]

ChIP-String Ties Down Chromatin Regulator Analysis

March 22, 2012

There are hundreds of chromatin regulators (CRs) out there, and yet we know so little about them other than that they control chromatin structure and function through interactions with histone mods. To help tie down the CR rules of engagement, some handy scientists developed the ChIP-string assay to provide a snapshot of several CRs in […]

Influenza Dodges Antiviral Response with Histone Disguise

March 22, 2012

Imitation is the sincerest form of flattery, they say. But instead of flattery, the influenza virus (and maybe many other viruses) imitates histones to make people sick. That kind of flattery we could do without. Researchers in NY and the U.K. discovered that influenza A (H3N2)—one of the strains that cause seasonal flu outbreaks—hijacks the […]

Bivalent PREs Protected by Perfect Timing

March 21, 2012

There’s no substitute for good timing. It’s a trait that can keep you out of a dangerous situation, or make you look good on the dance floor. But for cells it’s also critical for maintaining epigenetic states during replication. Italian researchers at the IRCCS Santa Lucia Foundation recently identified a critical time window right before […]