miRNPs Offer Support to miRNA SeedsFebruary 28, 2011Everyone appreciates a little extra support now and then, and a new study shows that miRNAs, or more specifically their seed regions, do too. The report in NAR uncovered that micro-ribonucleoprotein complexes (miRNPs) get miRNAs ready to take care of their mRNA targeting business by shoring up the structure of miRNA seed regions, which is […]
Turning Back the Clock: Epigenetics, iPSCs and AgingFebruary 25, 2011Aging can be a real downer, but for some individuals premature aging is a lot more serious than a few aches and pains the morning after some touch football. Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal genetic disorder where the victims speed through aging. It is caused by a point mutation in the […]
5-mC Stabilizes High-Maintenance MethyltransferasesFebruary 16, 2011Many things in life–like diets, exercise routines, and blogs–are easier to start than maintain. The same can be said for DNA methylation. De novo methyltransferases establish DNA methylation patterns in embryonic stem cells, but exactly how somatic cells maintain these patterns is puzzling. Now researchers at the University of Southern California have identified a new […]
Cocaine Keeps the LINEs JumpingFebruary 16, 2011New research surfacing in PNAS details the downward spiral cocaine induces in heterochromatin in the reward center of our brains. Over the years researchers have found that cocaine can regulate chromatin structure in the nucleus accumbens, a reward region in the brain and an area closely tied to addiction. DNA methylation machinery has also been […]
CoSBI Squeezes More Data From Histone MapsFebruary 14, 2011As the ‘histone code’ hypothesis gains steam, it’s become obvious that there isn’t much out there to help the chromatin research community look for combinatorial relationships between histone modifications. That’s where the Coherent and Shifted Bicluster Identification (CoSBI) algorithm comes in; to help wring even more data from genome wide histone mod maps. Not to […]
MethylC-Seq Delivers First Single Base Resolution Methylation Profiles of iPSCsFebruary 2, 2011There’s always something a bit “off” when you look at aging starlets who’ve had some work done. In the same way, researchers in California and Wisconsin recently found that induced pluripotent stem cells (iPSCs) generated from old somatic cells aren’t quite the same as youthful embryonic stem cells (ESCs)—the epigenetics are “off”. Sure, iPSCs and […]
Watch It: Sensitive 5-hmC Detection in ActionFebruary 1, 2011Hockey, Nascar, 5-hmC analysis…. Somethings are just better experienced in person. So if you’re in the market for pinning down 5-hmC in your studies, you’ll want to check out this short JOVE vid that show’s NEB’s EpiMark™ 5-hmC and 5-mC Analysis Kit tracking down 5-hydroxymethylcytosine levels in mouse Babl/C brain. Watch Video Click to view […]
Take a Bite Out of Cancer with the Epigenetics DietFebruary 1, 2011What’s your idea of a perfect meal? Whether you’re into the In-N-Out burger, fries, and milkshake trifecta, or you’re more of a “cleanse” type, the epigenetics enthusiast in you will be interested in a recent review by Trygve Tollefsbol and colleagues that reveals that certain foods contain ingredients that may prevent and treat cancer. Although […]
First Exon Methylation Gets Last Word On SilencingJanuary 31, 2011Arguments are often won by whoever gets in the last word, and while CpG Islands have made the most noise in the debate over how DNA methylation controls transcription, other gene regions like exons are now chiming in too. The classic model where methylated CpG Islands in promoters shut down transcription of a gene has […]
Ta-da! Blood Cells Transform into iPSCsJanuary 20, 2011Turning a cell into an induced pluripotent stem cell (iPSC) is tricky. It turns out that blood cells have an edge—they already epigenetically resemble iPSCs. When U.S. and Chinese researchers poked around the DNA of human CD34+ cells from umbilical cord blood and adult blood, they found that the promoters’ methylation patterns looked a heck […]