Headlines Archives - EpiGenie | Epigenetics, Stem Cell, and Synthetic Biology News

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Ever get that feeling that you forgot something? Well maybe you did, but it doesn't have to be recent epigenetics research if you scope out our Headlines each week.

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Blame Your Old Man: Age-Related Sperm Methylation Changes May Up Disease Odds

July 24, 2014

Delayed parenthood in developed countries means more old dads. Who cares you ask? You should, as this trend doesn’t just increase early morning traffic at Starbucks, it can also increase the incidence of autism, bipolar disorders, schizophrenia, some forms of cancer, or other disorders that accompany the offspring of older fathers. Way to go Dad; […]

Webinar – Bringing ChIP Seq Data into Focus: Advanced Normalization Strategies

July 23, 2014

If you’ve ever struggled to make sense of your ChIP Seq data, then check out this webinar presented by our colleagues at Active Motif, to get some ideas on how to bring some order to the chaos of ChIP-seq. Presented by Brian Egan, Ph.D, Epigenetic Services Manager at Active Motif Normalization of ChIP-seq Data Today, […]

Cutting Edge HIV Therapy with Zinc-Finger Nucleases

July 23, 2014

Although HIV can nowadays be successfully managed with a cocktail of antiretroviral drugs that inhibit replication, the virus remains latent in the genome of infected individuals waiting to come out full throttle whenever it is given the chance. Therefore the hunt is still on for a strategy to give HIV infected cells the final blow. […]

Accelerating Histone Modification Decryption

July 23, 2014

Unlike some reality show marriages that crack under the media spotlight, the union of automation and big data is still going strong, especially when it comes to cataloging histone post-translational modifications (PTM). Researchers from Princeton University show off a new systematic approach for figuring out just what all those histone PTM combinations are up to […]

Are Human Cord Blood iPSCs the Next Top Model?

July 23, 2014

It’s hard for most of us to imagine what life would be like without speaking, walking, breathing, and swallowing, but individuals suffering from motor neuron disease don’t have to imagine this scenario. Motor neuron diseases, like amyotrophic lateral sclerosis (ALS) (Lou Gehrig’s disease) and spinal muscular atrophy (SMA), strip thousands of people every year of […]

5′ UTR miRNA Targeting

July 21, 2014

The nightly news lately makes it seem like the world has gone upside down, and now we’ve got some science to back it. Honglei Zhou and Isidore Rigoutsos from Thomas Jefferson University recently revealed that mammalian miRNA targeting doesn’t always limit itself to 3′ miRNA action. It now seems that in addition to the traditional 3’UTR […]

Grab an Epigenetics Position at Active Motif

July 21, 2014

Our colleagues at Active Motif are searching for a new member for their team in the position of Product Specialist – Europe. If you dig epigenetics, and think you’ve got some business and marketing skills to go with it, then this may be a great fit for you! The crew at Active Motif is great […]

Chromatin Packaging in Embryonic Stem Cells and Sperm

July 16, 2014

Fitting all that chromatin into a tiny package is no easy ordeal, especially when pristine nuclear architecture is so crucial to things like cancer prevention. In order to learn more about the chromatin packaging of mouse embryonic stem cells (ESCs) and sperm, a team from the University of Massachusetts Medical School laid out some high-resolution nucleosome and transcription factor […]

Fetal Undernourishment Creates Temporary Transgenerational Effect

July 11, 2014

Transgenerational epigenetic inheritance is one hot topic, and it has long been shrouded in skepticism, but a number of cases and mechanistic insights into transgenerational epigenetic inheritance have helped molecular biology move past the limits of genetic determinism. Now a team from the University of Cambridge show that fetal nourishment results in a transgenerational epigenetic effect, rather than true […]

Reaction Biology Scores NIH Grant for Epigenetic Drug Database

July 11, 2014

Epigenetic databases are one of of our favorite futuristic tools and now a time traveling crew from Reaction Biology Corporation (RBC) land a grant from the National Center for Advancing Translational Sciences (NCATS) to create an impressive database of epigenetic drug interactions. The team at RBC is undertaking a colossal effort examining a library of 1,400 compounds, including almost every FDA approved drug. […]