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Hold Your ‘breadth’ – H3K4me3 Domain Size Matters

August 1, 2014

Apple may have finally thrown the gloves off in the race for larger screens, but it appears that this is old news for cells, who have been elevating the status of important genes for years by marking them with large billboards of H3K4 tri-methylation. These genes then get the VIP treatment from cellular machinery ensuring “enhanced […]

Webinar: Using CRISPR/Cas9 Technology for Editing Genes in Haematopoietic Cells and Mice

July 29, 2014

Presented by: Dr Marco Herold, Laboratory Head, Molecular Genetics of Cancer Division, The Walter & Eliza Hall Institute of Medical Research Abstract: The CRISPR/Cas9 technology provides an easy and rapid way to edit genes in vitro and in vivo. Initial experimental strategies utilized a transient transfection approach to modulate genes in vitro, but this proved […]

TAL Effectors Dig the Long Distance Thing

July 25, 2014

If you think the subway is crowded you haven’t seen what a TAL Effector (TALE) has to put up with when getting to work. In a new study involving the production of more than 200 TALE modulators, researches at Beijing University found the long sought explanation of why some TALEs effectively modulate transcription while others do not. […]

CRISPRs and TALENs Stay on Target in Stem Cell Genomes

July 25, 2014

Some of our most touted advancements in weaponry involve ‘surgical strike capabilities’, the idea being that the more precisely you attack a specific target, the less unintended damage there will be. Recent innovations in genome editing, such as CRISPRs and TALENs, may provide researchers with an improved genomic targeting system, enabling more precise aiming towards […]

Blame Your Old Man: Age-Related Sperm Methylation Changes May Up Disease Odds

July 24, 2014

Delayed parenthood in developed countries means more old dads. Who cares you ask? You should, as this trend doesn’t just increase early morning traffic at Starbucks, it can also increase the incidence of autism, bipolar disorders, schizophrenia, some forms of cancer, or other disorders that accompany the offspring of older fathers. Way to go Dad; […]

Webinar – Bringing ChIP Seq Data into Focus: Advanced Normalization Strategies

July 23, 2014

If you’ve ever struggled to make sense of your ChIP Seq data, then check out this webinar presented by our colleagues at Active Motif, to get some ideas on how to bring some order to the chaos of ChIP-seq. Presented by Brian Egan, Ph.D, Epigenetic Services Manager at Active Motif Normalization of ChIP-seq Data Today, […]

Cutting Edge HIV Therapy with Zinc-Finger Nucleases

July 23, 2014

Although HIV can nowadays be successfully managed with a cocktail of antiretroviral drugs that inhibit replication, the virus remains latent in the genome of infected individuals waiting to come out full throttle whenever it is given the chance. Therefore the hunt is still on for a strategy to give HIV infected cells the final blow. […]

Accelerating Histone Modification Decryption

July 23, 2014

Unlike some reality show marriages that crack under the media spotlight, the union of automation and big data is still going strong, especially when it comes to cataloging histone post-translational modifications (PTM). Researchers from Princeton University show off a new systematic approach for figuring out just what all those histone PTM combinations are up to […]

Are Human Cord Blood iPSCs the Next Top Model?

July 23, 2014

It’s hard for most of us to imagine what life would be like without speaking, walking, breathing, and swallowing, but individuals suffering from motor neuron disease don’t have to imagine this scenario. Motor neuron diseases, like amyotrophic lateral sclerosis (ALS) (Lou Gehrig’s disease) and spinal muscular atrophy (SMA), strip thousands of people every year of […]

5′ UTR miRNA Targeting

July 21, 2014

The nightly news lately makes it seem like the world has gone upside down, and now we’ve got some science to back it. Honglei Zhou and Isidore Rigoutsos from Thomas Jefferson University recently revealed that mammalian miRNA targeting doesn’t always limit itself to 3′ miRNA action. It now seems that in addition to the traditional 3’UTR […]