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R-Loops at Gene Promoters and Terminals Mark the Epigenome

July 18, 2016

In today’s loopy world, the wise words “Those who cannot remember the past are condemned to repeat it” have a particular resonance. Thankfully, our epigenomes are dynamic historians that get the message and make use of past transcripts by forming R-loops. R-Loops and the Epigenome R-loops are RNA-DNA hybrids: a 3 stranded nucleic acid structure. […]

Extra-Coding RNAs (ecRNAs) Sculpt Dynamic DNA Methylation of the Brain

July 18, 2016

We’ve got our mind on methylation and methylation in our mind, but we are often left wondering how DNA methylation got there in the first place. Well, that cognitive tongue twister has now been cracked by a class of RNA that likes to interact with DNA methyltransferases. Extra coding RNAs (ecRNAs) originate from the sense […]

Hey Methylation, Thanks for the Memories

July 18, 2016

Memories; we all have some we would rather forget, and some that we will hold onto forever. But how exactly is memory formed and what are the biochemical pathways that are in play? Recent studies have indicated that RNA and DNA adenosine methylation are important for the conversion of experiences, both good and bad, into […]

Chromatrap®’s FFPE ChIP Kits Unlock Your Sample Vault

July 18, 2016

If you’re like many of the researchers we’ve met over the years, you’ve been hoarding some of your favorite Formalin Fixed Paraffin Embedded (FFPE) samples deep in the recesses of a nondescript lab freezer, just waiting to be investigated. We get it; traditionally FFPE samples have been successfully used to analyze RNA and DNA, but […]

Top Upcoming Epigenetics Conferences

July 14, 2016

In today’s omic world databases are crucial, which is why always we keep our conference-ome up to date. Here’s a taste of what 2016 has left to offer for your next educational epigenetic excursion. EMBL’s Transcription and Chromatin (Heidelberg, Germany – Aug 27-30) Interested in transcription? Then this is the conference for you! This meeting […]

Top Upcoming Stem Cell Conferences

July 13, 2016

Conferences are ideal places to hear insights from the leaders in your field, to watch the up-and-comers present their new and exciting visions, and to network with potential collaborators (i.e., drink and eat and have some fun!). To assist you with these endeavors, EpiGenie brings you the pick of the bunch: some of the most interesting stem […]

scAba-seq: Single-Cell, Genome-Wide, and Strand-Specific 5hmC Sequencing

July 6, 2016

Usually, you don’t want your genome sequencing served up with a sugar coating; however, thanks to a clever a new 5hmC sequencing technique, we can indulge in some sweet single-cell and strand-specific insight. The study of 5hmC (5-Hydroxymethylcytosine) prevalence in DNA typically involves utilizing modified bisulfite sequencing, 5hmC specific antibodies, or restriction enzymes. Aba-seq makes […]

Epigenetic Assays Get Clinical: Comparison of DNA Methylation Assays and More

June 27, 2016

Four new papers co-published by an international consortium demonstrate and further the clinical potential of epigenetic assays. The series of manuscripts was led by Christoph Bock (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences) and Stephan Beck (University College London). Comparison of DNA Methylation Assays Suited for the Clinic While there […]

Evolution Uses Bivalent Chromatin to Control Mammalian Development

June 22, 2016

A big event always requires a bit of prior preparation, and for evolution, mammalian development is no exception. The mammalian body plans have undergone massive evolutionary rearrangements and diversifications requiring the evolution of complex gene expression profiles. Recent studies in specific tissues in mammalian species have now linked these expression changes to the evolution of […]

Synthesizing A Human Genome

June 16, 2016

One score and six years ago, humanity embarked upon the Human Genome Project (HGP), sequencing all 3 gigabases of our genetic instruction manual. More than 1000 human genomes later, a consortium of synthetic biology heavy-hitters has proposed a new grand challenge. Appending “-Read” to the first project, they now propose Human Genome Project-Write, a quest […]