One-Stop Sequencing: Simultaneous Genetic and Epigenetic InformationMarch 2, 2023Some shoppers like to browse several stores, whereas others follow the Amazon approach and want to just visit one place to buy everything on their list. The lab of Shankar Balasubramanian’s (University of Cambridge) must be in that second group because they developed a sequencing method that is a true one-stop extravaganza. It rings up […]
DNA Methylation Editing Provides Evidence for Transgenerational Epigenetic Inheritance in MammalsFebruary 26, 2023While we have become familiar with the link between DNA methylation and disease, an exciting epigenetic editing study now reports how DNA methylation contributes to transgenerational epigenetic inheritance in mammals and influences disease-associated traits across generations! In their previous study, a talented team led by Juan Carlos Izpisua Belmonte at the Salk Institute for Biological […]
Multiplexed Epigenome Editing Rouses a “Sleeping Dog” to Treat a Neurodevelopmental DisorderFebruary 20, 2023“Let sleeping dogs lie” is sound advice for those who want to stay out of trouble! However, an eye-opening epigenome editing study now suggests that rousing the “sleeping” methyl CpG-binding protein 2 (MECP2) gene from the inactive X chromosome may represent a therapeutic opportunity for girls with Rett Syndrome – an X-linked neurodevelopmental disorder that […]
You Aren’t Going Crazy – Losing It at the Epigenetic Level Really Drives Aging!February 6, 2023Information loss can drive us crazy – from ruining a potential culinary masterpiece to turning a Lego-building afternoon into a nightmare, but can “losing it” at the epigenetic level drive aging and turn a young whippersnapper into an old fogey? We know all too well about age-related epigenetic changes, and now a team led by […]
Taking “CoRSIV” Writing from Short Notes to “Novel” Epigenetic Findings in Disease RiskJanuary 30, 2023Previously, a perfectly-penned study uncovered a type of DNA methylation variation “written” in the genome, which varies from person to person but remains consistent across tissues. Deciphering these “CoRSIV” (correlated regions of systemic interindividual variation) notes supported a deeper understanding of epigenetic variance and the impact on disease, with blood DNA methylation profiles from these […]
scChIX-seq Brings Double the Fun to Single-Cell Histone Modification ProfilingJanuary 23, 2023How do you double your fun? An extra scoop of ice cream, coffee and a cake, or the epigenetic delights of single-cell profiling of not one but two histone modifications? In the latter case, the scChIX-seq (single-cell chromatin immunocleavage and unmixing sequencing) integrated framework may represent a wise choice for those looking to indulge while […]
Chromatin-Con 2023: Epigenetics of Aging Online ConferenceJanuary 19, 2023Our friends and colleagues at Active Motif will be hosting an online conference focusing on the epigenetics of aging. Tune in if you can…Just take a look at the list of speakers and we’re sure you won’t want to miss it! Click over to the Active Motif website for more details and to register: Chromatin-Con […]
eBook: Epigenetics of AgingJanuary 16, 2023Aging and longevity research has moved to the forefront of epigenetics in recent years. From DNA Methylation, to the Exposome and “translational inheritance” we are all avidly interested in this topic. In this eBook we review recent and intriguing research into this topic. Table of Contents Novel Multiomic Epigenetic Clock May Decipher How Epigenetic Aging […]
Active DNA Demethylation as a Source of DNA Damage at EnhancersJanuary 3, 2023Paint a self-portrait, build a house? If, instead, your more achievable New Year’s resolution was to be more active, new and exciting findings on how the abundance of single-strand DNA breaks (SSBs) at neuronal enhancers represents an intermediate of active DNA demethylation will be right down your alley! Researchers led by Wei Wu and André […]
Can Engineering Chromodomains Take Histone Methylation to “Affinity” and Beyond!?December 4, 2022The troupe of “toys” we use to explore the world of histone methylation just gained a new friend thanks to a playful team of epigenetic engineers who have taken histone modification-reading chromodomains to “affinity” and beyond! Researchers led by Gianluca Veggiani (Louisiana State University, USA) and Sachdev Sidhu (University of Waterloo, Canada) knew that histone-modification […]