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Genome Architecture of Single Cells May Shape Reprogramming to Totipotency

April 5, 2017

The soaring Eiffel Tower in Paris, the tumultuous Guggenheim in Bilbao, or the intricate genome structure of a single cell; which architectural marvel impresses you the most? For the labs of Leonid A. Mirny and Kikuë Tachibana-Konwalski, the latter looms above any such extravagant edifice, but the available analytical tools lacked the resolution required for […]

CLEVER Technique Maps the 5-Formylcytosine Landscape during DNA Demethyation

March 31, 2017

Mapping an undulating, dynamic, and partially hidden landscape represents a vexing problem to say the least, especially when the landmarks of interest are rare DNA demethylation by-products in a single cell! This is the task faced by those intrepid explorers hoping to map the genome-wide location of 5-formylcytosine (5fC), a fleetingly rare oxidized form of […]

GAM SLICEs Through Enhancer Threesomes

March 24, 2017

While chromosome conformation capture (3C) methods like single-cell Hi-C focus on coupled pairs of chromosome contacts, and even their promiscuous regions, candid snapshots of chromosomal threesomes have remained an intimate secret … until now. The genomic architects in the labs of Ana Pombo and Mario Nicodemi developed a new method and accompanying statistical model to […]

CAGE Releases an Accurate Atlas of lncRNA Origin and Function

March 21, 2017

Don’t you just hate when you’re trying to get from A to B and google maps can’t even figure out where you’re starting from? Well, just like your last trip to that hot new sushi place, the precise location of lncRNA origins has only been plotted with blurry lines. Thankfully, to aid the start of […]

Gene Body DNA Methylation Keeps Cells Fit and Healthy

March 9, 2017

Boots, check! Helmet, check! DNA Methylation, check? Any active individual will tell you that protecting your body is an integral part of keeping fit and healthy while enjoying your sport of choice. In the über-competitive world of DNA, a study from the teams of Francesco Neri and Salvatore Oliviero has proposed that DNA methylation on […]

Single and Ready to Mingle: Single-Cell Bisulfite Sequencing Gives Up Its Intimate Secrets

March 9, 2017

Ever fancy a go with a new technique only to find that the methods section of the paper is holding out on the most intimate details? While single-cell bisulfite sequencing (scBs-seq) has been lusted after by many a researcher, mingling with those single cells has proved a bit more challenging. But fear not, the labs […]

Engineered Cells Treat Diabetic Mice

February 23, 2017

Mmm… post-lunch blood glucose spike! Sitting down at my quiet computer, I can nearly hear my pancreatic islet cells working away, pumping out insulin to keep my blood glucose levels in check. Unfortunately, millions of people are not so well-protected from the glycemic havoc so mercilessly wreaked by chocolate cake. For people with type 1 […]

Optogenetic Epigenetic Editing of DNA Methylation Puts You in Control of Stem Cell Fate

February 16, 2017

In Greek mythology, the fates forge the strings of life that control our lives and choose the moment of its end. We mere mortals yearn for such powers and we are now one step closer to the light thanks to an optogenetic epigenome editing system that lets you write and erase DNA methylation to control […]

In Vivo Gene Editing Strategy has CRISPR-Cas9 on the Brain

February 16, 2017

Are you crazy for CRISPR-Cas9? Are you gaga for in vivo gene editing? You should probably get out more, but in the meantime we have just the study for you. A new Nature Biotechnology study from the lab of Jennifer A Doudna has described a major step toward the in vivo application of CRISPR-Cas9-mediated gene […]

Pool Party: CRISPR + DropSeq For Better Pooled Screening

February 16, 2017

For those living in the more Northern climes, this is just about the time when you would give nearly anything for a sunny pool party. When it comes to pool parties, CRISPR turns out to be a pretty good host, but with one important caveat – CRISPR pool parties tend to be life-or-death affairs. Pooled […]