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Bromodomain Inhibitor is the Male Contraception for the Ladies’ Mouse

August 22, 2012

Mice from your backyard to Paris are buzzing with excitement after a team of scientists at Baylor may have paved the way for them to “mingle” with fewer consequences. The research team, led by Martin Matzuk, set out to explore ways to target, BRDT, a testes-specific, and bromo-domain containing protein that plays a key role […]

More than Methyltransferases: DNMTs Run a Reverse on 5hmC

August 20, 2012

New research out of Taiwan has found some familiar enzymatic faces are involved in the pathway from 5hmC to cytosine. A talented team of scientists recently showed that two members of the DNA methyltransferase (DNMT) family, DNMT3a and DNMT3b are more than just methyltransferases; they fill a role as dehydroxymethylases as well. It has already […]

Redefining DNA Methylation in Cancer with Dr. Andrew Feinberg

August 1, 2012

Dr. Andrew Feinberg discusses how recent events are reshaping the way his team thinks about DNA methylation in cancer. This interview was shot on campus at Johns Hopkins University. This video was brought to you by epigenetics supporters at EMD Millipore. Redefining DNA Methylation in Cancer Well, there are a number of things I’m […]

University of Ulster Online Postgraduate Certificate in Stem Cell Biology

July 31, 2012

The University of Ulster just wrapped up a successful inaugural year of their Postgraduate Certificate in Stem Cell Biology with 17 students coming on board, 12 of whom have just graduated successfully and another 5 transferring to upgrade to a Postgraduate Diploma.The course is completed fully online by distance learning and will get you up to date […]

Non-Coding RNAs and Drug Addiction

July 31, 2012

Although a lot of behavioral studies are out there on drug addiction, no one really knows how addiction develops at the molecular level. A new review by researchers in Miami describes lots of evidence from more than 80 studies suggesting that non-coding RNAs, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), might have a […]

Pol II Transcription Slows at 5-Formylcytosines (5caC) and 5-Carboxylcytosines (5fC)

July 31, 2012

It’s summertime—a time when you just want to take things slow. Researchers now report that 5-formylcytosines (5fCs) and 5-carboxylcytosines (5caCs) like to slow things down, no matter what the season. They say that these mods put the brakes on RNA Pol II transcription and make it less specific. Sure, researchers have known about 5fC and […]

Exploring the Genotype-Chromatin Structure-Disease Risk Connection

July 26, 2012

Its easy to obsess over little details, and want to understand every nuance of a subject that you’re passionate about, but sometimes it’s helpful to step back and get a broader perspective on what you’re working on. This review article from Richard Meagher and Kristofer Müssar at the University of Georgia does just that by […]

More Epigenomic Differences Found in Twins?

July 24, 2012

Twins may look alike, and even share identical genomes, but according to new studies, their epigenomes can be surprisingly different. Examination of the DNA methylation patterns in sets of twins revealed that early environmental conditions can alter epigenomes, and have a big impact on individual variability. A research effort headed up by Jeff Craig and […]

Free White Paper: Genome-Wide Analysis of RNA-Protein Interactions

July 3, 2012

Nowadays, with RNAs interacting with chromatin interacting with DNA methylation marks, researchers are keener than ever to get their gloves dirty with RNA Immunoprecipitation (RIP). If you fit that bill, then you’ll want to check out this white paper authored by Dr. André P. Gerber out of the Institute of Pharmaceutical Sciences, ETH Zurich, Switzerland. […]

Wrapping Your Mind Around Brain DNA Methylomes

June 28, 2012

Not much is known about the normal DNA methylation differences between functionally different parts of the brain or how they relate to the patterns in peripheral tissues like blood. In a new study, scientists extensively mapped out the brain methylome to create a baseline resource for use in future research efforts. Researchers from King’s College […]