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Ever get that feeling that you forgot something? Well maybe you did, but it doesn't have to be recent epigenetics research if you scope out our Headlines each week.

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Histone Modification Imaging Pr-EDICTS Stem Cell Fate

January 27, 2017

Will it rain? Will my team win? Will I get that grant? There are instances where a glance into a fortune-teller’s crystal ball could definitely give you the upper hand. Although the crystal ball is a myth, researchers from the lab of Prabhas V. Moghe (Rutgers University, New Jersey, USA) have recently developed a means […]

Mapping mRNA Methylation in the Mouse: From ESCs to the Brain

January 23, 2017

As Ptolemy and other noteworthy cartographers will tell you, a detailed and up-to-date map is always useful. This navigational tool has guided many intrepid explorers from familiar regions towards the unknown with the promise of discovery and adventure! In the linear world of ribonucleic acid (RNA), intrepid researchers have mapped the locations of the N6-methyladenosine […]

RICC-seq Uses Gamma Rays to Smash out Nucleosome-Nucleosome Interactions

January 17, 2017

Gamma rays can give super powers to scientific insight, whether it be PET scans, the Epigenetic Hulk, or nucleosome-nucleosome interactions. While we’ve seen a lot about the primary structure of single nucleosomes and the tertiary structure of large chromatin loops, it seems that the 1–3 nucleosome (50–500 bp) architecture known as secondary structure has been […]

Anti-CRISPRs Provide A Kill Switch For Cas9

January 6, 2017

The post-holiday party period is always an excellent time to reflect that there can always be too much of a good thing. Whether it’s cookies, champagne, or Bing Crosby, sometimes you just need an off-switch. The same can be true of Cas9 – leaving it turned on after your gene editing is done, or leaky […]

HITI: Gene Knock-Ins for Old Cells

December 29, 2016

Just like kids during the holidays, young stem cells have all the fun with their fancy new CRISPR-themed gene editing gifts, while their older, wiser, more differentiated counterparts keep getting nothing but coal. (Well technically carbon nanotubes, but elementally the same). This neglect is partly the fault of more differentiated cells themselves; stodgy as they are, […]

Copy Number Variation and Environmental Exposure Unwrap the DNA Methylation Storage Box of Autism

December 29, 2016

Preparing for a big event takes a lot of work; whether it be the holidays or developing a brain’s epigenome, keeping a storage box ready to go for the situation just makes sense. In their latest publication, the lab of Janine LaSalle at the University of California – Davis unwrap the epigenetic storage box of […]

CRISPR Interference Sheds Light on lncRNA Function

December 24, 2016

CRISPR/Cas9 regularly “lights up” our homepage here at Epigenie with new breakthroughs in DNA methylation, stem cell gene editing, and 3-D chromosome structure, to name but a few of the recent highlights. Now, an exciting new study published in Science has employed CRISPR/Cas9 technology to illuminate the “dark matter” of our genome; the ubiquitous but […]

dCas9-Dnmt3a-Dnmt3L Methyltransferase Seeds a Nuclear Reaction

December 15, 2016

Some scientific breakthroughs are so transformative that there’s no containing their spread once they’ve seeded. By engineering cellular nuclear reactions with a biochemical twist, the most powerful deactivated Cas9 (dCas9) methyltransferase explodes from the lab of Tomasz Jurkowski at the University of Stuttgart. The free energy of this reaction forges not only a new tool […]

Frequently Interacting REgions (FIREs) Ignite Chromatin’s Promiscuity

December 10, 2016

Once thought to be monogamous molecules characterized by devote linear relationships, chromosomes turn out to be philandering conformation-changers with burning loins of desire concealed between their genes. Coming from the lab of Bing Ren at the University of California, San Diego, a massive analysis of genome-wide chromosome interactions captured by Hi-C uncovers a distinct piece […]

Step Up to the Plate: Chromatrap® ChIP Seq 96 Well Format

December 8, 2016

There comes a time in every researcher’s career when you need to step up the throughput, but the thought of high throughput ChIP can be paralyzing. “How much sample is this going to cost me?” “What happens if something goes wrong…that’s 96 samples!” The first thing you want to look for when transitioning to high […]