There’s More Than One Way to Scare A Mouse: Z-DNA and ADAR1 Add to Fear ExtinctionMay 5, 2020There’s already some histone modifications, and a dash of non-coding RNA, but new research adds another ingredient to the epigenetic recipe of fear memories and it’s called Z-DNA! Z-DNA occurs when the DNA molecule forms a left-handed double helix rather than the right-handed structure that we’re used to. This inside-out conformation is enriched at actively […]
Adolescent Cannabis Use Primes an Epigenetic Gateway to Cocaine AddictionMay 2, 2020When it comes to preparing for a future situation, our epigenome usually has our back; however, sometimes epigenetic alterations can prime some undesirable responses as a result of environmental exposure. With legalization occurring in many states and nations, research into how cannabis alters our epigenome has entered the spotlight. We have recently seen that cannabis […]
How the Journey Towards Sperm Maturation Can Leave Offspring Stressed Out!April 23, 2020Queues! Security! Lost passports! While many will be currently reminiscing about the fun and frolics enjoyed during old holidays to far-flung exotic destinations, we generally choose to forget the enduring stress of the outward journey. However, a fascinating new study now provides evidence that any stress endured by maturing sperm during their epic voyage is […]
Dop(Ey)mine: The Seventh Dwarf Of Histone Modifications Makes A Big Impact In The BrainApril 19, 2020Mirror mirror on the wall, who’s the newest histone modification of all? We know that methylation, acetylation, phosphorylation, ubiquination, and even citrullination have been toiling away in the chromatin mines, but a new study from the brainy team who discovered serotonylation suggests that dopamine is also hard at work on histone tails, where it highlights […]
Tet3 Acts Against Anxiety in Forebrain NeuronsMarch 27, 2020While there are a lot of reasons to anxious these days, thankfully our neurons are using epigenetics to respond and adapt to the barrage of new information in our environment. In fact, DNA cytosine hydroxymethylation (5hmC) might be necessary to keep cognition in check, and a new research suggests that one of the enzymes that […]
Phase Separation – The Next Generation for Epigenetic Modifications?March 27, 2020It may sound like a term straight out of a science fiction program such as Star Trek, but liquid-liquid “phase separation” is actually one of the hot new topics in epigenetics. Phase separation of proteins with certain characteristics leads to the formation of biomolecular liquid “droplets” that concentrate the levels of some proteins/factors while excluding […]
Not Aging Gracefully? Two Epigenetic Regulators May be to BlameMarch 16, 2020In the last 50 years, there has been a ~20% increase in global life expectancy but interestingly, there has not been a corresponding increase in the number of healthy years lived. Lubin Jiang and Shi-Qing Cai at the Chinese Academy of Sciences (Shanghai, China) sought to understand that disparity by examining the genetic factors involved […]
ChromID Helps Us Understand How Epigenetic Pots Find Their Protein LidsMarch 16, 2020The old saying “every pot will find its lid” suggests that a match exists for everyone looking for love, you just have to get out there and find your perfect partner! Online-dating may help scientists to find their significant other from the bench side; however, current laboratory approaches for the identification of protein-binding partners for […]
EpiGenie Guide: Chromatin ShearingMarch 6, 2020ChIP-Seq has transformed the field of epigenetics, providing unprecedented resolution and coverage for surveying protein- DNA interactions. Powerful, high-throughput sequencing is credited with most of the benefits, but there’s a lot more that goes into ChIP-Seq than sequencing. Chromatin shearing is one of the first critical steps in the ChIP-Seq workflow. Depending on your approach, […]
dCas9-ROS1 Cuts Out the Methylation Middlemen in Targeted DNA DemethylationMarch 3, 2020As the saying goes, the shortest path from A to B is a straight line and if you’re studying DNA demethylation, you know just how complicated things can get along the road from methylated to unmethylated cytosines. Mammals use Ten-Eleven Translocation proteins (TET) to oxidize 5mC, but the process creates pit stops that may be […]