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Non-coding RNAs Reveal How Stress Can Be Inherited

May 7, 2014

Stress hits every one of us, like when the Heartbleed virus makes you have to go back and reset all of your online passwords. Recent evidence has already linked the DNA methylation and histone alterations left behind by stressful events to transgenerational epigenetic inheritance, but now, scientists from the Brain Research Institute in Switzerland have observed […]

Get an Epigenetics Job at Abcam

May 5, 2014

Abcam is searching for an Epigenetics Technical Author for their Research Area Content Team. We’ve worked at and with a number of companies in the epigenetics space and we can’t say enough good things about Abcam. Plus…Cambridge (UK) is an amazing town with a rich history, a bustling academic environment and most important, a ton […]

Going ChIP-less Yields More Insights on Histone Code Combos

April 29, 2014

When it comes to studying chromatin structure and histone modifications, a new technique proves that sometime less really is more, ChIP-less that is. Antibodies for individual histone post-translational modifications (PTMs) have long been the star of chromatin technology, but PTMs often act in concert to form a dynamic histone code whose combinations can interfere with antibodies attempting to bind […]

Ancient History as Told by DNA Methylation

April 23, 2014

To some people ancient history is anything prior to Facebook, for others, it might mean pre-iPod, but this new study uses DNA methylation to look WAY back in time and analyze the beginnings of human evolution (And yes, that’s before the internet was invented). Using epigenomics to look back into pre-historic times has taught us […]

DNA Cubes May Take Genome Editing Outside the Box

April 22, 2014

Through the use of some creative chemistry researchers have devised DNA cubes that can deliver molecular packages with precision that would make FedEx jealous. A geometrically genius team from McGill University crafted a piece of DNA origami that will only release it’s molecular payload when triggered by a specific mRNA. Here’s how they did it: Cubes were […]

Kit Competition Reveals Hacks to Help Bisulfite Conversion

April 16, 2014

At first pass it may seem like all bisulfite conversion kits are essentially the same – and for the most part, that’s true. But according to a recently published evaluation, the conversion is all in the details, and if those are overlooked it can have a big impact on the results. Fortunately, researchers from the […]

SIF-seq Sifts Out Stem Cell Enhancer Gold

April 10, 2014

Searching for functional enhancers is sort of like panning for gold; there is enormous potential for riches, but the task is akin to finding a needle in a stack of needles. A team from the Berkeley National Laboratory decided to apply their own gold rush-style, enhancer mining techniques to develop a new method for the discovery of functional enhancers aided […]

Mood Killer: DNA Methylation Linked to Depressive Disorder

April 10, 2014

There aren’t a lot of laughs to be had when discussing the very real and increasing problem of depression, but some new research supported by the brain initiative on sets of twins may help to lighten the mood a bit. Studies have begun popping up showing that epigenetic marks can be used to show if someone has […]

CRISPR/Cas9 Caught Causing A Cure

April 9, 2014

The CRISPR/Cas9 genetic editing system has soaked up the media spotlight faster than anything not named Kardashian. But unlike that famous clan, recent research indicates that there may be good reason that the science paparazzi just can’t seem to get enough of CRISPR/Cas9. After making the leap from basic discovery to zebrafish to monkeys, a […]

Zymo Research Converts Sequencers into Epigenetic Analyzers

April 7, 2014

Next-Gen Sequencing (NGS) has revolutionized scientific research, but when it comes to epigenetic exploration, scientists have had to make do with sequencing library prep methods from other non-epigenetic applications. The crew at Zymo Research has found a way to adapt sequencers for epigenetic research, without having to completely retrofit the instrument. With the introduction of […]