Cell Surface Protein Profiling Gives Single-cell CUT&Tag a Pro UpgradeApril 25, 2022Nothing beats a Pro upgrade, and lately, researchers have given CUT&Tag the deluxe treatment. This chromatin profiling method received its first improvements with the releases of scCUT&Tag and then Spatial-CUT&Tag; now, we’ve been treated to a view of the cell surface protein profile in its latest form. A pro team of single-cell explorers from the […]
Single-cell Based DNA Methylation Deconvolution Method Scores Another Goal for EpigeneticsApril 25, 2022You might think you know the leading players in the field of computational epigenetics; however, each new season brings forward a squad of exciting new players eager to prove their worth. Recently, one of these players EpiSCORE-d the goal of extending in silico cell-type deconvolution of human epigenomic data to many tissues. While reference-based cell-type […]
APOE Tips Heterochromatin Balance Towards Stem Cell Senescence and AgingApril 11, 2022Like a healthy balance between work and play can enhance our day-to-day lives, a new study suggests that stem cells require a healthy epigenetic balance between silent and active chromatin domains to support their ongoing normal functions. More specifically, researchers headed by the well-balanced quartet of Moshi Song, Weiqi Zhang, Jing Qu, and Guang-Hui Liu […]
Has Cannabis Gone Up in Smoke? – Study Links Use to Accelerated Epigenetic AgingMarch 31, 2022Like there is no smoke without fire, another study has linked cannabis use to unwanted epigenetic alterations. We’ve seen that cannabis exposure alters DNA methylation in prenatal mouse brains (influencing subsequent behavior), the sperm of rats and humans (priming an autism spectrum disorder-like profile), and human adult brains (impacting brain function), and now epigenetic aging […]
DNA Methylation Provides New Insight into the Missing Heritability of ALSMarch 31, 2022The devastating and fatal neurodegenerative disease amyotrophic lateral sclerosis (ALS) has an estimated heritability rate of around 50%, suggesting that a considerable portion of disease risk derives from environmental and lifestyle risk factors that can leave their mark on the epigenome. Can DNA methylation analysis provide new insight into the missing heritability of ALS? In […]
Welcome to the Jungle! N4-acetyldeoxycytosine is a Wild New DNA Modification Identified in Plants and Detected in HumansMarch 14, 2022It’s time to welcome a new DNA modification to the epigenetic jungle! A collection of more than seventeen modifications have been spotted in the wilds of genomic DNA; however, only the biological effects of the prevalent 5-methyldeoxycytosine (5mC) (and its oxidated family members), along with N6-methyldeoxyadenosine (6mA) have been explored in any depth. Do other […]
CUT&Tag Launches to the Final Frontier: Spatial Epigenomic Profiling of Histone ModificationsMarch 14, 2022Space: the final frontier – CUT&Tag has just voyaged where no next-generation sequencing method has gone before to bring forth spatially-resolved histone modification profiles of intact mouse tissues! An expeditionary force led by Rong Fan (Yale University) combined in situ cleavage under targets and tagmentation (CUT&Tag) chemistry, microfluidic deterministic barcoding, and next-generation sequencing to develop […]
Webinar: Chromatin Immunoprecipitation (ChIP) Workshop – Dr. Toryn PoolmanFebruary 28, 2022If you’re new to chromatin immunoprecipitation (ChIP), or you’re thinking about giving it a try, you will want to take the time to watch this webinar first! Our friends at Proteintech put together an excellent workshop led by Dr. Toryn Poolman at University College London that covers a ton of tips and tricks that will […]
“Is this the real-life? Is this just fantasy?” – CultureAGE Shows How In Vitro Studies Reflect In Vivo Epigenetic AgingFebruary 21, 2022Profiling epigenetic aging with in vitro cell models may allow for a deeper understanding of the difficult-to-decipher in vivo process, but only if one truly reflects the other; this leaves us wondering: “Is this the real-life? Is this just fantasy?” In their epigenetic rock opera, bohemians from the lab of Morgan Levine (Yale School of […]
Can Disrupting Chromatin Interactions Stop SARS-CoV-2 in its Tracks?February 21, 2022Viral infections can appear like a runaway train, careering through the human body without a brake in sight; however, the meandering journey taken for the development of antivirals has now discovered a new way to stop runaway SARS-CoV-2 infections in their tracks thanks to CRISPR technology and a trip through the chromatin landscape of infected […]