Headlines Archives - EpiGenie | Epigenetics, Stem Cell, and Synthetic Biology News

Headlines

Ever get that feeling that you forgot something? Well maybe you did, but it doesn't have to be recent epigenetics research if you scope out our Headlines each week.

Search Articles

Exon Skipping via Intergenerational Epigenetic Silencing Rescues Duchenne Muscular Dystrophy

July 29, 2020

While missing a gym class can happen from time to time without leaving you feeling too guilty (!), you really shouldn’t “skip” a fascinating new study that now describes how a maternally-transmitted epigenetic “exon skipping” effect may act as the foundation for new therapeutic approaches for a devastating genetic muscle-weakening disease. A majority of Duchenne […]

rChIP-Seq Ratifies RNA as a Requirement for PRC2 to Rock and Roll

July 20, 2020

Once in a while, an epigenetic technique comes along to rock your world more than your favorite Led Zeppelin or Foo Fighters album! Now, a band of researchers fronted by the dynamic duo of John L. Rinn and Thomas R. Cech (University of Colorado, Boulder, CO, USA) has just released a chart-topping masterpiece with their […]

H4K16ac Marks an Intergenerational To-Do List for Developing Fly Embryos

July 7, 2020

Do the laundry? Check. Buy fabric softener? Got it. Write that next manuscript? Working on it… We’ve all got a lot on our to-do lists these days, but it’s nothing compared to the checklist that developing drosophila embryos have to contend with. On top of coordinating histone methylation marks, they’ve got to prepare for a […]

Early-Life BPA Exposure Accelerates Epigenetic Aging and Creates a Ticking Timebomb for Metabolic Disease that a Western Diet Ignites

July 3, 2020

While we hope that any silly errors and childish pranks of our formative years don´t follow us into adulthood, it now seems that certain experiences during early development are indeed carried into adulthood without our knowledge, where an activating trigger can lead to trouble and strife! Specifically, exposure to any number of environmental stressors during […]

Disrupted LADs Drive Epigenetic Alterations in Human Early-onset Aging

June 22, 2020

The “driver” represents a crucial part of a successful Formula One team, a decent score at golf, and even a well-planned bank heist (!), and working out those factors that drive the onset of various diseases and disorders may provide critical mechanistic insight and even aid the development of novel therapeutic approaches. In the early-onset […]

Epigenetic Hole-in-One: Methylation of a Single CpG Disrupts GATA-1 Binding and Regulates Gene Expression

June 11, 2020

The GATA-1 transcription factor is like the Tiger Woods of the erythroid cell lineage, topping the leaderboard and driving the expression of important developmental genes. Other molecular competitors, like the NuRD complex, are already on the course, but a new study shows how methylation of a single CpG is able to score a hole-in-one to […]

Dynamic Modeling of DNA Methylation “Turnover” Reveals Tasty Epigenetic Morsels

June 11, 2020

While the word “turnover” may send the culinary-minded to the kitchen and the business-savvy straight to the accounts books, epigeneticists studying the turnover of DNA methylation have been left between a rock and a hard place! Researchers are in this unappetizing predicament as while we can accurately paint a genome-wide picture of DNA methylation levels, […]

A Rewired Metabolism Links the Aging Epigenome to Vision Loss

May 16, 2020

They say hindsight is 20/20, but for those of us looking over at a lifetime of memories, things might seem a little blurrier through our aging eyes. That’s because, unlike the fine wines, delectable whiskies, and smelly cheeses that we love to catabolize, the human epigenome tends not to age very well and a wide […]

Preprint Alert: Single-nucleus Mouse Brain Atlases of DNA Methylation and Chromatin Accessibility

May 15, 2020

When exploring the epigenetic landscape, it’s easy to get lost in the jungle of cell types. Thankfully, some exciting new preprints now bring forth much needed single-nucleus atlases to guide your voyage of the mouse brain. We’re no strangers to cunning cartography that has emerged from the lab of Joe Ecker (Salk Institute, California). They’ve […]

Cannabis and Tobacco Produce a Double Hit on the Epigenome

May 12, 2020

While the epigenetic impacts of cannabis have been seen in sperm and adolescents, the effects on adults have not been well studied in large-scale studies. It’s commonly believed that smoking cannabis is less damaging than smoking tobacco; however, this is not backed by an abundance of actual data. Smoking tobacco is associated with numerous DNA […]