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Webinar: Advanced ChIP Normalization Controls

June 17, 2015

Abstract: Gene expression is regulated by a combination of transcription factor binding and the distribution of epigenetic modifications across regulatory regions. Much of what we know about the epigenome and gene regulation stems from our ability to determine the genome-wide distribution of histone modifications and transcription factors using chromatin immunoprecipitation followed by next generation sequencing […]

Webinar: Locus-Specific Biochemical Analysis of Genome Functions Using enChIP with CRISPR

June 17, 2015

Abstract Elucidation of molecular mechanisms of genome functions such as transcription and epigenetic regulation requires identification of components mediating the genome functions. To this end, we recently developed the locus-specific chromatin immunoprecipitation (ChIP) (locus-specific ChIP) technologies to identify molecules interacting with a given genomic region of interest in vivo. Locus-specific ChIP consists of insertional ChIP […]

KeyGenes Helps Predict Differentiated Humans iPSCs

June 15, 2015

Cells differentiated from embryonic stem cells are generally phenotypically immature, so identifying what cell type they are can be a bit like trying to figure out what exactly the picture your child drew for you in kindergarten is supposed to be. “That’s lovely darling but…” Luckily, for biologists at least, a team of Dutch researchers […]

CpH Methylation Gets A Tissue Specific Makeover

June 15, 2015

In the latest show of the power of teamwork we see some of the biggest names in epigenetics join forces to unravel the mysteries of the methylome across different tissues, including the molecular cartographers who tackled the brain and the researchers who brought forth the predictive powers of Epigram. The talented team from the Salk Institute and UCSD have […]

A TAD of Disruption Shows the Importance of Boundaries

June 1, 2015

If you’ve ever seen a polydactyl cat you might (understandably) live in fear of cats with thumbs. If we want to prevent the takeover by our feline friends we need to understand the cause of this limb anomaly. Luckily, researchers led by Stefan Mundlos have done just that by asking if 3D chromosome structure data […]

DNAi Combines Self-Destructing DNA with CRISPR

May 29, 2015

Have you ever watched a spy move and felt yourself craving spy gadgets, such as explosive chewing gum, or a tricked out Aston Martin? Well if you are a genome-engineering scientist you can now get your very own spy gadget – self-destructing DNA! But this cool creation isn’t just to fulfill your 007 dreams, it […]

miRNA-Switches Makes Stem Cell Selection Pure and Simple

May 28, 2015

As any sports coach, hopeful lottery winner, or child in a candy store will tell you, an effective selection strategy is vitally important to a successful outcome. Selection is also an important concept for scientists and clinicians hoping to take advantage of the ability that human pluripotent stem cells (hPSCs) have to differentiate into multiple […]

MINimize Your Genome Engineering Efforts with CRISPR and Bxb1

May 28, 2015

CRISPR is for genome engineering what Mike Tyson was for boxing: simple, efficient and almost a guarantee to see a knockout in the first round. While in boxing a knockout typically results in an involuntary power nap of the opponent, the phenotype of a gene knockout is often not so clear-cut. Besides potential problems caused […]

Could Chromatin Organization be the Key to Eternal Youth?

May 13, 2015

For thousands of years great men such as Alexander the Great and Ponce de León have searched far and wide in their search for the fountain of youth and the hope of eternal life. But where they previously failed, an enterprising group of scientists may have now just succeeded! A report published recently in Science […]

Twins Team Up to Help Unravel DNA Methylation in Schizophrenia

May 12, 2015

While they can’t see through lead or stop bullets with their chest, twins do have a superpower of their own – when it comes to unraveling the complex genomic and epigenomic changes underlying diseases and disorders. In their latest adventure monozygotic twins are helping to understand the DNA methylation changes associated with schizophrenia. The epigenomics of […]