Headlines Archives - EpiGenie | Epigenetics, Stem Cell, and Synthetic Biology News

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Ever get that feeling that you forgot something? Well maybe you did, but it doesn't have to be recent epigenetics research if you scope out our Headlines each week.

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NIH Protein Capture Reagents Program

September 26, 2012

The NIH is seeking broad community input (that means you) to prioritize a list for renewable affinity reagents for human transcription factors. This outreach effort is part of the Protein Capture Reagents Program (http://commonfund.nih.gov/proteincapture/). This program was initiated by the NIH Common Fund in response to concerns raised by scientific community regarding the lack of access to […]

Webinar: Exploring Genome-Wide Organization of Chromatin Structure by ChIP

September 26, 2012

Our friends at Abcam are hosting a lovely webinar for those of you seeking to ChIP away at chromatin enlightenment. Topics to be discussed include: Introduction to chromatin, ChIP (Chromatin IP) and usages of the method Overview of genomic approaches to map in-vivo chromatin structure (ChIP-seq and ChIP-chip) Detailed description of genome-wide mapping of chromatin by ChIP-seq and ChIP-chip […]

Free White Paper: Histone Acetylation and Methylation – Epigenetic Modulators of Gene Expression

September 26, 2012

Histone acetylation and methylation are important cellular processes, but it can be hard keeping track of the structural ups and downs from HATs and HDACs. This free white-paper provides an informative, concise review of the key players in histone acetylation and methylation and their impact on specific residues. Download here >>>

RNA Methylation Adds Some Stability to a Chaotic Cell

September 26, 2012

We could all use a little more stability in our lives, and now researchers in Germany say that tRNAs get more stable when they are methylated on specific cytosines. This stability helps ensure that cells keep making proteins for proper development and differentiation. The role of cytosine-C5 methylation on tRNAs has been more mysterious than […]

NOMe-seq Goes Genome Wide

September 19, 2012

NOME-seq (Nucleosome Occupancy and Methylome Sequencing) made a big splash when it was introduced just over a year ago because of its novel ability to profile nucleosome positions and DNA methylation at the same time, on a single DNA strand. Now researchers from the University of Southern California Epigenome Center have powered-up the technique by […]

DNA Methylation Runs the Genomic Defense

September 12, 2012

Novel research findings over the last last five years have introduced more exceptions than rules in the field of DNA methylation in gene silencing. Whether DNA methylation stars as the cause or effect in the thickening regulatory plot continues to be discussed in labs around the world. A British team of researchers led by Dr. […]

Predicting Gene Expression with Chromatin Features

September 11, 2012

As any weather forecaster can tell you, making accurate predictions is tough. But researchers now report that they’ve confirmed the power of chromatin features to predict gene expression. They’ve also come up with some new insights, too. Sure, some histone mods are associated with transcriptional repression, whereas others typically mark active spots. But many studies […]

Promoters Reach Out to Far -Away Elements

September 11, 2012

Now that the Olympic games are over, researchers in the ENCODE consortium have announced that they’ve just finished another Olympic effort of their own—the large-scale mapping of functional elements in the human genome. And just like the flexible “Fierce Five” U.S. women’s gymnastics team, it turns out that the genome is very bendy, looping around […]

Prediction Models Re-Write the Book on Nucleosome Occupancy and miRNA Targeting

August 23, 2012

A pair of newly released papers prove that you don’t always have to run more wet lab experiments to learn something new, you just need to look the data in a different way. The two research groups both used simulations and prediction algorithms, like the ones found on our Epigenetics Databases and Tools list, to […]

Bromodomain Inhibitor is the Male Contraception for the Ladies’ Mouse

August 22, 2012

Mice from your backyard to Paris are buzzing with excitement after a team of scientists at Baylor may have paved the way for them to “mingle” with fewer consequences. The research team, led by Martin Matzuk, set out to explore ways to target, BRDT, a testes-specific, and bromo-domain containing protein that plays a key role […]