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DNA Methylation Runs the Genomic Defense

September 12, 2012

Novel research findings over the last last five years have introduced more exceptions than rules in the field of DNA methylation in gene silencing. Whether DNA methylation stars as the cause or effect in the thickening regulatory plot continues to be discussed in labs around the world. A British team of researchers led by Dr. […]

Predicting Gene Expression with Chromatin Features

September 11, 2012

As any weather forecaster can tell you, making accurate predictions is tough. But researchers now report that they’ve confirmed the power of chromatin features to predict gene expression. They’ve also come up with some new insights, too. Sure, some histone mods are associated with transcriptional repression, whereas others typically mark active spots. But many studies […]

Promoters Reach Out to Far -Away Elements

September 11, 2012

Now that the Olympic games are over, researchers in the ENCODE consortium have announced that they’ve just finished another Olympic effort of their own—the large-scale mapping of functional elements in the human genome. And just like the flexible “Fierce Five” U.S. women’s gymnastics team, it turns out that the genome is very bendy, looping around […]

Prediction Models Re-Write the Book on Nucleosome Occupancy and miRNA Targeting

August 23, 2012

A pair of newly released papers prove that you don’t always have to run more wet lab experiments to learn something new, you just need to look the data in a different way. The two research groups both used simulations and prediction algorithms, like the ones found on our Epigenetics Databases and Tools list, to […]

Bromodomain Inhibitor is the Male Contraception for the Ladies’ Mouse

August 22, 2012

Mice from your backyard to Paris are buzzing with excitement after a team of scientists at Baylor may have paved the way for them to “mingle” with fewer consequences. The research team, led by Martin Matzuk, set out to explore ways to target, BRDT, a testes-specific, and bromo-domain containing protein that plays a key role […]

More than Methyltransferases: DNMTs Run a Reverse on 5hmC

August 20, 2012

New research out of Taiwan has found some familiar enzymatic faces are involved in the pathway from 5hmC to cytosine. A talented team of scientists recently showed that two members of the DNA methyltransferase (DNMT) family, DNMT3a and DNMT3b are more than just methyltransferases; they fill a role as dehydroxymethylases as well. It has already […]

Redefining DNA Methylation in Cancer with Dr. Andrew Feinberg

August 1, 2012

Dr. Andrew Feinberg discusses how recent events are reshaping the way his team thinks about DNA methylation in cancer. This interview was shot on campus at Johns Hopkins University. This video was brought to you by epigenetics supporters at EMD Millipore. Redefining DNA Methylation in Cancer Well, there are a number of things I’m […]

University of Ulster Online Postgraduate Certificate in Stem Cell Biology

July 31, 2012

The University of Ulster just wrapped up a successful inaugural year of their Postgraduate Certificate in Stem Cell Biology with 17 students coming on board, 12 of whom have just graduated successfully and another 5 transferring to upgrade to a Postgraduate Diploma.The course is completed fully online by distance learning and will get you up to date […]

Non-Coding RNAs and Drug Addiction

July 31, 2012

Although a lot of behavioral studies are out there on drug addiction, no one really knows how addiction develops at the molecular level. A new review by researchers in Miami describes lots of evidence from more than 80 studies suggesting that non-coding RNAs, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), might have a […]

Pol II Transcription Slows at 5-Formylcytosines (5caC) and 5-Carboxylcytosines (5fC)

July 31, 2012

It’s summertime—a time when you just want to take things slow. Researchers now report that 5-formylcytosines (5fCs) and 5-carboxylcytosines (5caCs) like to slow things down, no matter what the season. They say that these mods put the brakes on RNA Pol II transcription and make it less specific. Sure, researchers have known about 5fC and […]