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lncRNA Gets Classy: Chromatin Signatures Distinguish Species

December 4, 2013

Everyone wants to be judged based on their own merits, and not just what group they happen to be a part of. With the help of a talented crew from the University of Oxford, lncRNAs have just been given a wonderful holiday gift to help them break free of their one-size-fits-all stereotype; two distinct classes […]

Modifying Our View of Histones with Dr. Jerry Workman

December 3, 2013

Dr. Jerry Workman discusses the questions surrounding the preservation of histone marks, and the balance between histone turnover and transgenerational inheritance. The Dynamic Histone Code I think one of the most exciting things for me that’s being approached in the field more recently is how are histone marks preserved? We talk about these things carrying […]

The Loose Ends in the Chromatin-Transcription Relationship with Dr. Steven Henikoff

December 3, 2013

Dr. Henikoff discusses some of the gaps in our understanding of transcription and chromatin that still need to be filled in. The Unknowns of RNA Polymerase-Nucleosome Interactions Well, you would think with so much work done on the relationship between transcription and chromatin, the fact that there’s so many meetings on it and all. We […]

Chemical Creation of Epigenetic Marks: One Step Closer to Synthetic Life

December 2, 2013

What if Craig Ventor got a hold of the epigenome during his quest to create synthetic life? Is humanity be ready for an artificial life-form potentially as complex as its creators? Will Duck Dynasty and Honey Boo Boo be picked up for another season? These are all very important questions. And a few of our […]

Transgenerational Epigenetics is Bringing Sexy Back

November 26, 2013

For mice, domestication is a ten generation process, and while we’re left wondering at what stage Toronto Mayor Rob Ford is caught up in, we’ll try to steer clear of any low brow jokes. During the process of domestication many adaptations occur, but not all are beneficial. In fact, as a thought provoking group from […]

Genome Synthesis vs. DNA Methylation: A Battle for One-Carbon with Dr. Patrick Stover

November 19, 2013

Dr. Patrick Stover discusses the competition between genome synthesis and DNA methylation for the use of available folate and one-carbons. The Balancing Act of Folate Metabolism So one of the primary focus of our laboratory is trying to link how changes in metabolism affect specific disease outcomes. And we’re most interested in neural tube defects […]

Is DNA Methylation Key to Antipsychotic Treatments?

November 18, 2013

Evidence continues to stack up about the environmentally responsive ways of our epigenome, but most of the time when we hear about it, it’s usually about some bad news. However, Dr. Shiva Singh and his colleagues at Western University (Canada) have come across an interesting case where epigenetics mechanisms appear to cause the therapeutic effects of […]

Epigenetic Editing Targets DNA Demethylation, Induces Gene Expression

November 16, 2013

TET family proteins grabbed a bit of fame back in 2009 for their role in the demethylation pathway that generates one of our favorite base modifcations 5hmC. Since then, researchers have sought out ways to harness TET’s tremendous potential as a mechanism for active regulation of DNA methylation…if only Miley had followed in its’ footsteps. […]

Epigenetics & Cancer & Gene Networks …Oh Me(thylation)!

November 15, 2013

Now that we’ve landed smack dab in the middle of the age of big data, some interesting techniques have emerged to interrogate the mind-boggling amounts of information from our (epi)genome. Dr. Ranjan Perera and team at the Sanford-Burnham Medical Research Institute (Florida) applied some of that new analysis wizardry to learn more about the complexity of […]

Methylcytosine Makes its Mark on RNA Methylation

November 6, 2013

Methylcytosine – It’s not just for DNA anymore. Despite being almost exclusively associated with DNA for decades, methylcytosine (5mC) has recently been shown to be an important base modification in RNA as well. Exploding interest in the RNA version of 5mC, what it does, and how it works, has been sparked by a sharp uptick […]