cfDNA Methylation Analysis Captures the Double Trouble of Inflammaging!July 1, 2024Analyzing cell-free (cf)DNA methylation from liquid biopsies represents a non-invasive approach to profile various diseases, but what if it could help us understand the devious duo of inflammaging – aging and inflammation? A talented team has dealt with this “double trouble” by applying enzymatic methyl-seq (EM-seq) to evaluate cfDNA methylation patterns. Researchers headed by Jian-Ping […]
Epigenome Editing Modules Team Up to Cut Through Gene Regulatory ChaosJune 24, 2024Sometimes an indirect approach can give a direct answer. For example, two recent papers use dCas9 based epigenome editing to cut through gene regulatory mechanisms. No cutting required. These epigenomic editing toolkits use single-cell readouts to provide a clearer story of how our favorite chromatin modifications and enhancers do their jobs. Mixing and Matching Modifications […]
Mitochondrial tRNAs as Epigenetic Memories of Sperm’s Epididymal Road TripJune 24, 2024If Hollywood has taught us anything, it’s that a road trip during our younger years can leave enduring memories that influence our adult lives. Now, a “blockbuster” study reveals that environmental pressures during maturation in the epididymis endow spermatozoa with “epigenetic” memories that influence offspring health via the intergenerational epigenetic inheritance of tRNAs. Researchers “driven” […]
DNA Methylation Differences in Imprinting Control Regions Contribute to Ethnic Disparities in Alzheimer’s Disease RiskMay 28, 2024Non-Hispanic Black (NHB) patients have a two-fold higher risk of developing Alzheimer’s disease than non-Hispanic White (NHW) patients for unknown reasons; now, a fascinating epigenetics study reveals the involvement of DNA methylation at imprinting control regions (ICRs). Researchers headed by Randy L. Jirtle and Cathrine Hoyo (North Carolina State University) explored ethnic variation in disease […]
G4-DNA: How an Unforgettable DNA Structure Regulates Gene Expression and MemoryMay 28, 2024The Eiffel Tower may live long in the memory, and La Sagrada Familia will be remembered for eons (when they finish it!), but can any structure truly rival DNA? Now, a new study describes how one of DNA’s many unforgettablestructural forms – G-quadruplex DNA (G4-DNA) – helps to regulate the gene expression profiles controlling fear […]
Epigenetics Alone Can Drive Cancer—No Mutations NeededMay 13, 2024Epigenetics has moved into the driver’s seat. In a first-of-its-kind study, a talented team show that knocking down polycomb group proteins in Drosophila causes tumors to form, and bringing the proteins back doesn’t fix it. The finding demonstrates that transient epigenetic changes can irreversibly drive cancer—without genetic mutations. Although we’ve suspected that epigenetic mechanisms could take […]
Non-linear Alterations in DNA Methylation Provides Evidence of Aging in Stages!May 6, 2024Certain concepts – the speed of light, the electron’s charge, or the need to change cell media at the weekend – represent common constants in life. Many add the constant decay associated with the aging process to this list; however, analysis of DNA methylation in the mouse intestine now reveals that the aging process may […]
The Force is Strong with Histone H1.0: How Extracellular Stress Regulates Cell Mechanics through Chromatin StructureMay 6, 2024Scientists have longed to use “The Force” – provided by intracellular entities known as midichlorians – to help around the lab; now, an epigenetic alliance reports that an intracellular fibroblast component – Histone H1.0 – uses The Force and orchestrates cell mechanics when facing Sith-like evils such as physical/chemical stressors. The force is strong with […]
Pregnancy Epigenetically Ages Mothers – But Breastfeeding May Reverse ItApril 22, 2024Our mothers might be onto something when they jokingly blame us for their gray hair and wrinkles. In two recent studies, DNA methylation-based epigenetic clocks show that pregnancy, with its far-ranging emotional and physical changes, increases the biological ages of mothers. On the bright side, the effects were reversible in those who breastfed, according to […]
This is Your Epigenetic Wake Up Call! Don’t Sleep on NAP-seq When Searching for ncRNAsApril 21, 2024Has searching for ncRNAs left you needing forty winks? Maybe take a short rest and dream-a-little-dream, but don’t sleep on a brand new technique known as napRNA sequencing or NAP-seq, which represents a wake-up call to the epigenetics field by providing the ability to describe novel classes of human regulatory non-coding or ncRNAs! Wakey-wakey! RNA […]