A very difficult-to-treat childhood leukemia may benefit from the discovery of a small but potent epigenetic change that launches the cancer but could potentially be reversed relatively easily, preventing cancer-promoting genes from being turned on. Children with the subtype of acute lymphoblastic leukemia (ALL) known as MLL-AF4 have a cure rate of just under 50 […]
Ever get that feeling that you forgot something? Well maybe you did, but it doesn't have to be recent epigenetics research if you scope out our Headlines each week.
Like a conscientious librarian, miRNA can’t seem to resist saying “Shhhh!” whenever the opportunity arises, whether in post-transcriptional or, as a new study suggests, in transcriptional silencing of genes. Although miRNAs were initially thought to suppress gene expression primarily through translational inhibition, recent evidence suggests additional roles for miRNAs in regulating gene expression in the […]
Over the years mutants like E.T., the Hulk, Yoda, and the X-Men to name a few, have all left a lasting impression in our lives. That’s why when a group of John’s Hopkins researchers, led by Jef Boeke, produced a library of synthetic histone H3 and H4 mutants to probe the function of each residue […]
Every great star has a sidekick who sometimes threatens to steal the show: Batman had Robin, Sherlock Holmes had Dr. Watson, and Hillary had Bill. Likewise, some proteins appear to have an intron-encoded miRNA sidekick that neutralizes the “bad guys” so that the protein can effectively perform its cellular function, as demonstrated in a recent […]
The Evil Twin is a staple of the soap opera genre—you know, the long-lost, villainous sister who kidnaps her virtuous twin and assumes her life, only to be discovered years later when the Good Twin escapes from imprisonment on an alien-inhabited desert isle. But in real life, how can identical twins with the same genes […]