Between reading Dilbert cartoons and refilling their Swingline staplers, many of corporate America’s finest day dream of holidays to distant islands, but they’re not alone. Researchers studying DNA methylation have made minimal attempts to hide their infatuation with CpG islands, after all, these regions tend to associate themselves with prestigious protein-coding regions of genes. An […]
Ever get that feeling that you forgot something? Well maybe you did, but it doesn't have to be recent epigenetics research if you scope out our Headlines each week.
Most primary miRNA transcripts remain a mystery because they’re generally degraded by the time they leave the comfort of the nucleus. Where do the transcripts start? Do they have a single “peak” of initiation, or are there a variety of sites where they’re likely to begin? Limitations in the currently available molecular biology tool set […]
In the past few years, ncRNAs have progressed from interesting anomalies to what some researchers think constitute the majority of the mammalian transcriptome. However, as reviewed by John Mattick and coworkers at the University of Queensland and the Ludwig Institute for Cancer Research (both in Australia), it’s increasingly difficult to distinguish coding from noncoding RNAs […]
It’s December, the time of year when much of the States is blanketed in a frosty mantle of the white stuff. But as recently reported in Molecular Cell, the ACA45 RNA appears to have pulled the ultimate snow job. Nikolaus Rajewsky, Gunter Meister, and colleagues revealed that ACA45, which was previously thought to function exclusively […]
What makes some tumors as gentle as purring kittens and others of the same cancer type as ferocious as saber-toothed tigers? A miRNA (miR-101) was recently shown to take a bite out of cancer by inhibiting the EZH2 histone methyltransferase. The study by Arul Chinnaiyan and co-workers at the University of Michigan Medical School, the […]