Epigenetics Reminds Adipocytes of their Obese Past After Weight LossDecember 8, 2024The age-old saying “a moment on the lips, forever on the hips” just got a modern update thanks to an epigenome-based study of obesity! New research now describes the existence of epigenetic memory in the adipose tissue of obese individuals that persists after significant weight loss. A team led by Ferdinand von Meyenn (ETH Zurich) […]
DNA Methylation and Chromatin Map of the Developing Brain Revealed with Single-Cell MultiomicsNovember 22, 2024Maps can tell you where to go and what landmarks you’ll find along the way. In the same way, a new multiomic map describes how DNA methylation and 3D chromatin conformation changes in the prefrontal cortex and hippocampus as the human brain develops. The map could help researchers determine the heritability of neuropsychiatric conditions, such […]
“Epi-bit” Encoded Images of Tigers and Pandas Reveal the Epigenetic Future of DNA-based Memory StorageNovember 10, 2024A memorable musical number from Cats muses on the loss of “Memory;” however, an unforgettable new feline-related study now describes the encoding of images of tigers (and pandas!) using printed epigenetic bits (“epi-bits”) on DNA as a novel storage approach for our data and dearest recollections. Can epi-bits make any memory loss a thing of […]
Psychosis Moderates the Association Between Cannabis Use and DNA MethylationOctober 28, 2024Analyzing the DNA methylation alterations induced by cannabis use has provided a wealth of evidence of potential harms, with recent studies focusing on neurodevelopmental problems after prenatal exposure, increased risk of adverse health outcomes, and accelerated epigenetic aging. Now, a study reports the first epigenome-wide association study (EWAS) exploring the interplay between cannabis use, DNA […]
Children Prenatally Exposed to Cannabis Have Altered DNA MethylationOctober 7, 2024As more states legalize and decriminalize cannabis, more questions are being raised about its effects, especially on pregnancy. Now, a clear-thinking team sees through the haze and shows that maternal cannabis use during pregnancy is associated with epigenome-wide differential DNA methylation in the blood of exposed children, especially in genes involved in neurodevelopment. Studies have shown […]
Epigenetic Two-factor Authentication Secures Male Fertility from the Insider Threat of TransposonsOctober 7, 2024Two-factor authentication represents a modern approach to securing our digital lives from outside threats; however, research now suggests that this concept may not be so modern. A new study now reveals that male germ cells employ a piRNA-mediated epigenetic “two-factor authentication” strategy to secure the precisely timed DNA methylation-induced silencing of insider threats that impact […]
Metformin Keeps Aging Primate Epigenomes “In Form”September 30, 2024Those of us feeling the all too familiar effects of time may look to cut back on certain “excesses” and keep fit (in both body and mind) to maintain a healthy aging process. Now, a team of fitness enthusiasts has revealed that long-term treatment with the diabetes drug metformin maintains an aging population of monkeys […]
Amyloids Could Solve the ‘Missing Heritability’ MysterySeptember 23, 2024Science is full of mysteries just waiting to be solved. One of these mysteries is the “missing heritability” problem—it turns out that some traits seem hereditary, yet cannot be traced back to nucleic acids or even known epigenetic modifications. Now, a talented team studying C. elegans has spotted protein clumps called amyloids that could be […]
Genome-Wide DNA Methylation Changes from Vaping and Smoking Have Striking SimilaritiesSeptember 3, 2024Vaping has been touted as a safer alternative to smoking, but some recent studies are showing that the biological effects have similarities. Now, a team clears the air and reports that DNA methylation changes in vapers’ oral cells resemble those found in smokers, which suggests that vaping could have comparable long-term health effects. Smoke gets in […]
Epigenetic Machinery Fights Back! SARS-CoV-2 RNA Modifications Inhibit Replication and PathogenesisSeptember 3, 2024Recent reports have highlighted how SARS-CoV-2 infection and the resulting COVID-19 can turn epigenetics against us; however, new research now reveals that the epigenetic machinery can also help us fight back against viral attacks – in the guise of specific RNA modifications. A team of epigenetic tusslers guided by Yu Chen (Wuhan University) knew of […]