epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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The Human Imprintome Maps out the Epigenetic Roots of Disease

August 20, 2022

A well-illustrated map may have helped the Spanish easily locate El Dorado or David Livingstone pinpoint the source of the Nile; now, rugged researchers have delicately “sliced” through the jungle of the human genome to create a map of imprint control regions (ICRs) – creating the “imprintome” – to hasten our exploration of the epigenetic […]

Multimodal Nanopore Profiling of Circulating Tumor DNA

August 1, 2022

The Oxford Nanopore (ONT) sequencing platform may have more modalities than a Swiss army knife. In a multimodal masterpiece of a new study, researchers now demonstrate how DNA methylation, copy number alterations, nucleosome footprinting, and fragmentation profiles derived from liquid biopsies of cancer patients can deconvolute cellular composition and identify cancer-specific methylation changes from circulating […]

eBook: Epigenetics of Cannabis

July 21, 2022

Changes in epigenetic regulation are hallmarks of the transition from normal to diseased cells. Exploration of the role of epigenetics in those who may use Cannabis, or related products such as THC or CBD, has proven to be informative for better understanding of their potential effects. In this EpiGenie ebook, we present summaries of several […]

Location, Location, Location! – How Site-specific mRNA ac4C Acetylation Impacts Translation

June 29, 2022

Where you spend your time away from work – a lake-side cottage far from the hustle and bustle or a party pad in the bohemian part of town – is a crucial decision. Now, new research on roaming RNAs demonstrates that when you call the epitranscriptome your home, the age-old rule “location, location, location” also […]

Now In Print! – New Technologies Leave their Mark on Imprinting Control Regions

June 19, 2022

Genomic imprinting typically lets our parents leave their mark on our genomes; however, new technological advances are now allowing us to leave our mark on imprinting! The first of our epigenetic exposés that went into print reports on how multiple modalities uncovered complex epigenetic crosstalk that regulates allele-specific gene expression at potential imprinting control regions […]

Dr. Steve Chan: The Epigenetic Regulation of Breast Cancer

June 9, 2022

Using unbiased ChIP-Rx analyses to discover a novel role for CTR9 in the epigenetic regulation of PRC2 subtype switching in breast cancer Our colleagues at Proteintech hosted a webinar from Dr. Steve Chan from The University of Wisconsin-Madison, who reviewed their recent paper “The transcriptional elongation factor CTR9 demarcates PRC2-mediated H3K27me3 domains by altering PRC2 […]

The Long and the Short of It – Long DNMT3A1 Isoform Binds Bivalent Neurodevelopmental Chromatin

May 23, 2022

Sometimes it’s best to get straight to the point, so let’s dive into this study of DNA methyltransferase 3a (DNMT3A) isoforms with variable lengths, which reveals a chromatin interaction domain that regulates bivalent gene expression and supports early postnatal survival in mice! Previous studies that didn’t beat around the bush described how postnatal development requires […]

Epigenetic Editing Approach Causally Connects Adolescent Alcohol Exposure to Psychiatric Disorder Risk

May 23, 2022

The modularity of current epigenetic editing technology allows us to evaluate the causality of connections from multiple angles. Now, epigenetic editing in rats using dCas9 activators and repressors has provided a welcome new perspective on how adolescent drinking can induce the onset of psychiatric conditions in adults. Binge drinking during adolescence (a critical period for […]

NANOG’s Prion-like Behavior Builds Bridges to Pluripotency

May 11, 2022

In both the literal and figurative sense, building bridges can really get you places! Knowing this, genome engineers and epigenetic architects recently created a blueprint demonstrating how a pioneer transcription factor – NANOG – uses prion-like behavior to form gel-like protein condensates that create interstrand DNA “bridges” to reorganize chromatin and clear a rapid path […]

EPIC Technique Infers Gene Expression from Cell-free DNA Fragmentation

May 9, 2022

It’s time to put down that well-thumbed copy of Homer’s Odyssey, as there is a new epic in town. Now, the “epigenetic expression inference from cell-free (cf)DNA-sequencing” (EPIC-seq) technique heroically enables gene expression analysis using a process known as “fragmentomics.” Circulating cfDNA comes as nucleosome-associated fragments that reflect the chromatin configuration in the cell of […]

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Epigenetics and ncRNA Headlines

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