epigenetics

Epigenetics and ncRNA Headlines

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Histone Methyltransferase Loss Disconnects the Autistic Brain

February 12, 2019

Connection and communication represent two crucial concepts in the massive and complex network that is the mammalian brain; therefore, the disruption of neural connections during early development may promote the onset of neurodevelopmental disorders. Previous studies have linked the histone methyltransferase SETD5 with autism spectrum disorders (ASD), which inspired researchers from the lab of Alysson […]

ChIP-seq SNFs Out the Epigenomic Impact of SWI/SNF Loss in Paediatric Brain Tumors

February 8, 2019

Cancer researchers have been SNFing around the role of the SWI/SNF complex for a long time. By SWItching to a ChIP-seq approach, novel details about how biallelic loss of a key gene promotes a cancerous epigenome have been uncovered. SWI/SNF (or BAF) is a chromatin remodeling complex and a key regulator of early development that […]

Too Much Tau Over Relaxes Chromatin in Neurons in Aging and Alzheimer’s Brains

February 3, 2019

Taking a break can be a great thing for our aging brains, it gives us a chance to unwind and open ourselves up to new ideas. However, it’s possible to have too much of a good thing, where overly relaxed chromatin can wreak havoc on an aging neuron and drive pathological changes! One of the […]

LncRNA-mediated Trisomy Silencing: Is the Reversal of Down Syndrome-associated Disease Just an Epigenetic Switch Away?

January 24, 2019

While “the rule of three” principle may make three the magic number for fairy tales and Hollywood blockbusters, trisomy of chromosome 21 causes Down syndrome (DS) and leads to the development of a range of severe associated disease and disorders in affected patients. However, research out of the laboratory of Jeanne B. Lawrence (University of […]

Teasing Apart the Brain: DNA Methylation Maps of Healthy Neurons Implicate Brain Region Differences in Psychiatric Disorders

January 24, 2019

While conducting epigenomics research, we are often faced with a number of brain teasers. To solve these cognitive conundrums, many of us turn to diseases and disorders to learn about healthy conditions. However, the methylation maestros in the labs of Andrew Feinberg and Kasper Hansen at John Hopkins University (Maryland, USA) now demonstrate the utility of […]

Monkey Memes: Social Status Epigenetically Primes a Stress-Responsive Chromatin Profile

January 15, 2019

Are you constantly checking your Twitter/Instagram/Reddit feeds for the newest memes and best cat videos to share for the most likes? Well, don’t spend too much time stressing over your social media status; especially if you are a rhesus macaque, because new research suggests your immune cells might take a major epigenetic hit if you’re […]

Of Rats and Men: Prospective Fathers Should Pass on Cannabis to Preserve Sperm DNA Methylation

January 15, 2019

While most of the focus on developmental epigenomics puts mom in the spotlight, a recent surge in sperm studies are showing that dad’s dreams of a care-free lifestyle are up in smoke. We’ve already seen that a high-fat diet can alter the sperm epigenome, and now a factor that may encourage such half-baked decisions takes the […]

Colorectal Cancer Cells Single in on an ‘Omics’ Bundle Upgrade

January 14, 2019

It often seems the best deals come in bundles. Bundle your internet, phone service, and cable package and those long hours in the lab become a bit less tempting. But now there’s a new sequencing bundle that will make you never want to leave the lab. scTrio-seq2 is a single-cell multiomic bundling that meets your […]

Tune in to Genetically and Environmentally Tunable Polymorphic Imprinting with nc886

December 10, 2018

While tuning into signals is the name of the game for (epi)genomics, an exciting new study now suggests that genetic and environmental factors can tune our epigenomes by polymorphic genomic imprinting. Unlike other imprinted genes that always display monoallelic methylation, the nc886 DMR is polymorphic and imprinted in only ~75% of people. New research into this […]

It’s All in the Phylum: Lessons on Epigenetic Lineage From an Ancient Relative

December 6, 2018

You won’t find amphioxus listed as close relative on 23andMe, but this humble invertebrate chordate may have paved the way for the successful vertebrates we’ve become. Although amphioxus split from the vertebrates over 500 million years ago on the phylogenetic tree, it still can offer some clues as to how vertebrates acquired such unique and […]

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Epigenetics and ncRNA Headlines

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