epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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Non-Coding RNA: 2011 Editor’s Favorites

January 11, 2012

Understanding of non-coding RNAs grew by leaps and bounds in 2011, but the more that we learn; the more we get the feeling that this is just the tip of the iceberg. Take a look at some of our favorite articles from the last year that highlights the variety of roles that non-coding RNA play. […]

Chromatin: 2011 Editor’s Favorites

January 11, 2012

Chromatin definitely left it’s mark in 2011, making big advances with applications in cancer, stem cell, environmental, and autism research, just to name a few. Check out our favorite chromatin articles from 2011 to help you get ready for what’s coming in 2012. Histone Harm from Nickel Exposure It’s been known for a while that […]

Valproic Acid Derivatives and Cisplatin: Better Together

January 10, 2012

Like PB&J or Brangelina, some things are just better together. Now a new study suggests that combining derivatives of the histone deacetylase (HDAC) inhibitor valproic acid with the chemotherapy drug cisplatin may kill human lung cancer cells better than either drug alone. HDAC inhibitors such as valproic acid show great promise as treatments for a […]

MiRNA Workout Helps Lower Hypertension

January 10, 2012

Getting the heart pumping with a little exercise is good for the body—it lowers blood pressure and helps fight off heart disease. That makes getting fit a popular New Year’s resolution, but still no one really understands the molecular mechanism that’s behind the scenes. Now, reports show that exercise’s benefits may be due to its […]

Getting Down to Histone Antibody Specifics

December 15, 2011

Histone antibody specificity has been the topic of publications as well as discussions at meetings and conferences (probably water coolers and coffeemakers, too) within scientific community recently. Clearly, antibody specificity is important to researchers, but what are vendors doing to address it? To get an idea of what goes into making better histone antibodies we […]

5fC & 5caC Follow Up Strong in 5hmC Sequel

December 14, 2011

Life was simpler back when there were only four bases. Nowadays researchers studying DNA methylation have to keep track of four methylCytosine derivatives alone, and the research is just starting to heat up. The last couple of years the TET family of proteins has proven effective at catalyzing 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), apparently as […]

Databases for Epigeneticists

December 13, 2011

The holidays have come a little early for epigeneticists! Nucleic Acids Research just published papers on several databases that put a wealth of information on various epi-phenomena right at your fingertips. Chances are, at least one of these has info that will make your research life a whole lot easier. HIstome The Histone Infobase (HIstome), […]

Profiling Exon Methylation with Liquid Hybridization Capture-Based Bisulfite Sequencing

December 12, 2011

Sometimes, you just want to get to the good stuff right away. Now, researchers in China report that they’ve developed a way to target their sequencing when analyzing methylomes rather juggling 6 hard drives. With their new liquid hybridization capture-based bisulfite sequencing (LHC-BS) method, they just grab exons and analyze them for methylation. The method […]

EpiGenie Review: Non-coding RNAs and miRNAs in Cancer

December 9, 2011

Based on the latest research, the cancer::non-coding RNA conncection is undeniable. It’s just all the specifics around things like miRNA regulation that are still left to be understood. While dedicated epigenetics investigators are hard at work solving those mechanistic riddles, we’ve decided to take a look back at what’s been learned so far. Here are […]

Hypermethylated Pockets within Hypomethylated Genomic Regions Defines Cancer Cells

December 5, 2011

What makes a cell become a cancerous? We’d all love to know that, right? Well, new research has gotten a little bit closer to figuring out key epigenetic differences between cancer and normal genomes. It turns out that the DNA methylation patterns of these cells differ drastically, no surprise there, but it’s the genomic context […]