NOMe-Seq Secrets RevealedFebruary 17, 2014You’ve read the NOMe-seq (Nucleosome Occupancy and Methylome sequencing) papers. Seen the splashy advertisements. Now, we’ve consulted with the experts at Active Motif to get the inside scoop on how to get started, and get the most out of your NOMe-seq experience. NOMe-Seq was originally published and developed by researchers in the Peter Jones lab […]
Epigenetics Special Issue: Non-coding RNAs in Epigenetic RegulationFebruary 17, 2014From the very beginning, EpiGenie has held a place in our hearts for non-coding RNAs. That’s why we were stoked to see that the Landes journal Epigenetics dedicated an entire issue to the enigmatic and always interesting little transcripts. The Epigenetics: Special Focus on Non-coding RNAs in Epigenetic Regulation issue features a boatload of reviews […]
Environmental Epigenetics TimelineFebruary 11, 2014Thanks to growing interest from the general public, environmental epigenetics is a red-hot topic with no signs of cooling off anytime soon. We’ve certainly covered our fair share of research with an environmental slant to it, so if you want to review, research, or just plain get up to speed on the subject, these articles […]
SIRT1, miR-34a Clear Out the JNK from Fatty LiversFebruary 11, 2014When it comes to liver disease, it seems most of the attention (and research) goes to the variety that is associated with the consumption of alcohol. While that’s a big concern for those of us enjoy the occasional adult beverage, it’s left non-alcoholic fatty liver disease (NAFLD) under-studied. But now that’s changing. According to Rui […]
Clinical Epigenetics TimelineFebruary 10, 2014The underlying goal for most epigenetic research projects is to eventually lead to a therapeutic clinical application. Here we provide a history of clinical epigenetic advances in this interdisciplinary field as told through our articles and Conference Highlights.
Epigenetics of Cancer TimelineFebruary 9, 2014Epigenetic mechanisms have been studied in cancer for decades. Unfortunately, we haven’t been around that long, but check out these great articles that capture the recent history of epigenetic breakthroughs in cancer.
The Rise of lncRNAs TimelineFebruary 9, 2014Long non-coding RNAs, also known as lncRNAs, are gaining a truck load of momentum in the field of the epigenetics. Here we highlight the hottest research, methods papers, and the occasional interview centered around these long and curvy regulatory RNAs.
Evolution of Advanced Sequencing TimelineFebruary 7, 2014In a few short years. advanced sequencing has become nearly ubiquitous. Here we provide a history of how emerging sequencing technologies have driven epigenetic research and understanding.
Capture-C Catches Chromatin ContortionsFebruary 5, 2014Chromosome Conformation Capture (3C) is a cool technique that has lead to more spin-offs than the CSI TV franchise. This technique has been used at enhancers, silencers, boundary elements, and promoters at the individual loci level. But now a cunning team of researchers from Oxford University (UK) have just shown how to take it to an ‘omic level’. Here’ […]
World’s First CRISPR MonkeysFebruary 5, 2014The Crispr/Cas9 genetic engineering system has gotten a lot of buzz lately for its potential in epigenetic editing and now a team of researchers in China have just made a huge breakthrough, using the technique to create genetically engineered monkeys. The scientists approach was to inject an engineered bacterial immune system (known as CRISPR/Cas9) into one-cell-stage […]