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Variable Methylation Regions and Missing Heritability with Dr. Andrew Feinberg

May 10, 2012

Dr. Andrew Feinberg discusses how epigenetics might be related to missing heritability of disease via variable methylation regions. This interview was shot on campus at Johns Hopkins University. Variable Methylation Regions and Missing Heritability So a conundrum in modern human genetics is how epigenetics might be related to missing heritability of disease, what’s commonly […]

HPV Integration Brings Cancerous Changes to the DNA Methylome

May 9, 2012

Vaccination against human papillomavirus (HPV) can protect against many forms of the virus, which can cause cervical cancer. But not everyone gets vaccinated, and there’s still a risk of becoming infected with an HPV type that the vaccination doesn’t cover. Early epigenetic events associated with HPV infection are still mysterious, so researchers in the United […]

Pregnancy-linked miRNA Cluster in Exosomes May Spark Adenomas

May 9, 2012

We’ve all had things come back and haunt us—like our high school yearbook picture (the horror!). Now, researchers in Germany say they hypothesize that the same thing could happen with a chromosome 19 miRNA cluster. These miRNAs appear to dampen a mother’s immune response to a developing fetus, but the researchers think that this “immunomodulatory” […]

Virtual Poster Presentation: Comprehensive DNA Methylation Profiling of 3.7 million CpGs with the SureSelect Target Enrichment System

May 8, 2012

What new technique reveals more information than methylation microarrays by detecting individual CpGs, increases throughput with reduced costs compared to Whole Genome Bisulfite Sequencing and reveals methylated regions undetected by RRBS and Me-Dip? Tune in to a virtual presentation delivered Dr. Kyeong Soo Jeong, R&D Scientist, Genomics Group, Agilent Technologies as he presents a poster that […]

DNA Methylation qPCR Panels Keep Stem Cells in Check

May 8, 2012

Every day, in labs all over the world, stem cells are changing. Sure they may lack (lineage) commitment, but these ultra-promising cellular blank canvases aren’t living sedentary epigenetic lifestyles. DNA methylation in stem cells is on the move with age and passages and you might not even know it. Sequencing still isn’t quite feasible for […]

oxBS-Seq Breaks Through 5hmC Sequencing Barrier

April 26, 2012

5-Hydroxymethylcytosine (5hmC) has always been a bear to sequence, mostly because it’s virtually indistinguishable from its close relative, 5-methylcytosine (5mC) using classic bisulfite sequencing techniques. Now a new sample preparation method has hit the scene that can discriminate between cytosine, 5mC and 5hmC at single base resolution, called oxidative bisulfite sequencing (oxBS-Seq) that essentially smashes […]

Sequencing DNA Methylation Past, Present, Future with Dr. Wolf Reik

April 26, 2012

Dr. Wolf Reik discusses the challenges in DNA methylation sequencing and the next big swings in epigenetic modification sequencing and discovery. This interview took place at the Keystone Symposia’s Epigenomics and Chromatin Dynamics joint meeting in January, 2012. This video was brought to you by epigenetics supporters at EMD Millipore. Sequencing DNA Methylation […]

Argonaute AGO2 Gives miRNAs a Little Trim Around the Edges

April 17, 2012

Isn’t there always one person in a group of friends who’s a little weird or different? It turns out that AGO2, is a little different from its Argonaute paralogs, AGO1, 3, and 4. Researchers in Singapore are reporting that unlike other Argonautes, oddball AGO2 trims mammalian miRNAs, changing their functions during development. The team knew […]

miRNAs Decide Which Honey Bees Do Which Honey-Do’s

April 17, 2012

It seems nobody has been busier than the honey bee lately when it comes to being a model epigenetic organism. (Watch your back c. elegans!) Over the last year or so, we’ve seen how HDAC inhibitors affect the bee caste system, as well as how social cues alter DNA methylation patterns in the brains of […]

Active Motif MeDIP-Seq Services Will Put You On the Right MethylPath™

April 17, 2012

Let’s say you want to get the ball rolling for studies on a new disease. You know you want to search for any important changes in methylation patterns; but with a whole genome worth of ground to cover, how do you decide where to look first? Active Motif now offers the MethylPath™ MeDIP-Seq Service that […]

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