epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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Exploiting Nucleotide Recycling to Kill Cancer

July 28, 2015

Have you ever had a doubt about what exactly you can recycle? The cell is faced with the same problem when it encounters epigenetic nucleosides. It does not really know if they can be recycled as they are or discarded. New research by the team of Skirmantas Kriaucionis shows that although such nucleotides are normally […]

Webinar: Key Steps for Validating Antibodies and Optimizing the ChIP Workflow

July 27, 2015

Abstract: Research in the field of epigenetics has grown at a rapid pace since the discovery of the first histone acetyltransferase enzymes 18 years ago. Since then, significant advances have been made in our understanding of the basic mechanisms of epigenetics (histone acetylation, histone methylation, chromatin remodeling and DNA methylation) and the impact of epigenetic […]

Salivating Insights into the DNA Methylation Connection in Fetal Alcohol Syndrome

July 20, 2015

Things often show up where you least expect. Whether it’s finding your keys in the freezer, your phone in the couch, English kings underneath a car park, or the secrets of brain development in spit. Sometimes all you have to do is look. Previously, the lab of Shiva Singh from the University of Western Ontario […]

Race, Gender and Non-Coding RNA: tRNAs Don’t Play it Politically Correct

July 17, 2015

Human genetics just got a whole lot more complicated with a report published last week by Isidore Rigoutsos’ team in Oncotarget. As if differences in expression profiles between cells, tissues and differentiation stages weren’t already enough, it seems that race and gender also affect genomic output. Specifically, the team focused on transfer RNAs (tRNAs). tRNAs […]

Resistance is Futile: Epigenetic Therapy Makes Cancer Cells Defenseless

July 9, 2015

A team of American scientists have shown that an epigenetic therapy might hold promise for combatting drug resistance in cancer. Cancer cells are masters of drug evasion and adept at using alternative pathways to give them an edge during treatment, complicating many therapeutic approaches. Overcoming drug resistance in cancer cells, would save millions of lives […]

CRISPR-Display: For the lncRNA Enthusiast that has Everything

July 6, 2015

From wall hung TVs to the latest wearable; displays have been a key technology differentiator for years. Now we’d like to introduce you to CRISPR-Display, one of the latest applications of CRISPR technology for the lncRNA lover that wants to elevate their functional game. Interest in lncRNAs continues to surge, but like other uncharted areas […]

5fC is Stable in Mammalian Brains

June 24, 2015

DNA methylation has been undergoing dramatic change lately. 6mA shook things up by showing Cytosine can’t claim all the glory and now a talented team from the UK have shown 5-formylcytosine (5fC) is starting to follow in 5hmC’s independent footsteps. The team profiled 5hmC, 5fC, and 5caC using: in vivo isotope labeling of methionine to penetrate […]

Webinar: Advanced ChIP Normalization Controls

June 17, 2015

Abstract: Gene expression is regulated by a combination of transcription factor binding and the distribution of epigenetic modifications across regulatory regions. Much of what we know about the epigenome and gene regulation stems from our ability to determine the genome-wide distribution of histone modifications and transcription factors using chromatin immunoprecipitation followed by next generation sequencing […]

Webinar: Locus-Specific Biochemical Analysis of Genome Functions Using enChIP with CRISPR

June 17, 2015

Abstract Elucidation of molecular mechanisms of genome functions such as transcription and epigenetic regulation requires identification of components mediating the genome functions. To this end, we recently developed the locus-specific chromatin immunoprecipitation (ChIP) (locus-specific ChIP) technologies to identify molecules interacting with a given genomic region of interest in vivo. Locus-specific ChIP consists of insertional ChIP […]

CpH Methylation Gets A Tissue Specific Makeover

June 15, 2015

In the latest show of the power of teamwork we see some of the biggest names in epigenetics join forces to unravel the mysteries of the methylome across different tissues, including the molecular cartographers who tackled the brain and the researchers who brought forth the predictive powers of Epigram. The talented team from the Salk Institute and UCSD have […]

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Epigenetics and ncRNA Headlines

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