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Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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EMdeCODE Deciphers Epigenetic Code, Finds New Role for Old Histone Modifications

December 19, 2012

With all the “LOL”s, “IMHO”s, and “YOLO”s out there, it’s like we’re all speaking in code. When we get stumped on what these things mean, we can always turn to Google. But what if you want to decipher the hypothetical “epigenetic code?” Well, one researcher has the answer—EMdeCODE, a new algorithm that does just that […]

Hypermethylation in miRNA 26a Provides New Route in Prostate Cancer Progression

December 12, 2012

There’s usually more than one right way to get where you want to go. Unless of course, you’re using Apple Maps, then all routes are questionable, but at least have a pretty interface. It turns out there are at least two ways to wind up with prostate cancer, and neither are that attractive—having a gene […]

5hmC Analysis Timeline

December 10, 2012

EpiGenie has probably covered developments in 5hmC more than any topic the last couple of years, so we’ve compiled this timeline for you. Scroll along to see what you may have missed if you’ve been out of the loop or lab for a sabbatical.

New and Improved: Multiplexed Reduced Representation Bisulfite Sequencing (RRBS)

December 7, 2012

These days, we’re all about multi-tasking—talking on our cell phones while placing our cappuccino order at Starbucks and tweeting about it all on our tablets. In that same vein, researchers report an optimized protocol for multi-tasking (well, technically “multiplexing”) reduced representation bisulfite sequencing (RRBS) for ramped-up DNA methylation data. RRBS is great, churning out methylation […]

The Daily Rhythms of Transcription and the Epigenome

December 7, 2012

We all have a daily routine. For much of the EpiGenie office staff, that includes getting out of bed, brushing our teeth, going to work, grabbing a coffee, clocking a few hours on Facebook and complaining that there aren’t enough hours in the day. Now, researchers say that transcription and epigenetic modifications in mouse liver […]

Low Cell ChIP-Seq

November 28, 2012

Chilly, wintry temps have us longing for palm trees, sandy beaches, and the limbo call of “How low can you go?” Researchers in Norway and Germany have the answer—and a new ChIP-seq method that allows them to analyze genome-wide DNA-protein interaction data for samples that have very few cells, without culturing (which could alter epigenetic […]

Epigenetic Drift in Stem Cells

November 28, 2012

Living for a while in a new environment can have a big effect on how you dress, talk, and act. Just listen to Madonna’s British accent. Likewise, taking bone marrow mesenchymal stem cells (BM-MSCs) out of the body and into the in vitro cell-culture environment can change them—but not necessarily for the better. In order […]

MNase-Seq Produces High Resolution Nucleosome Positioning Maps

November 27, 2012

Nucleosomes don’t have GPS, so how do they know where to go? Are they haphazardly strewn across the genome or is there some logic to it? Researchers now say they have some answers. They found that DNA sequence and DNA-binding proteins play roles in determining where nucleosomes end up, and that most nucleosomes are more […]

One Step ChIP with Abcam’s EpiSeeker ChIP Kit

November 20, 2012

Antibody companies like Abcam run a ton of ChIP experiments, so they’re all too familiar with the amount of variability that can lurk in every step of the ChIP protocol. So what’s the safest way to reduce variability and get consistent results? Reduce the steps of course; and that’s exactly what the EpiSeeker ChIP Kit […]

Lentiviral Vectors Can Cause Epigenetic Modifications

November 20, 2012

Stem cell programming has been buzzing the last few years and with recent work suggesting that epigenetic and ncRNA factors are manipulative enough to star in TV drama, we expect the excitement to continue. But according to a recent report, researchers may need to keep close tabs on how the very methods they use to […]

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