epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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Bromodomain Inhibitor is the Male Contraception for the Ladies’ Mouse

August 22, 2012

Mice from your backyard to Paris are buzzing with excitement after a team of scientists at Baylor may have paved the way for them to “mingle” with fewer consequences. The research team, led by Martin Matzuk, set out to explore ways to target, BRDT, a testes-specific, and bromo-domain containing protein that plays a key role […]

More than Methyltransferases: DNMTs Run a Reverse on 5hmC

August 20, 2012

New research out of Taiwan has found some familiar enzymatic faces are involved in the pathway from 5hmC to cytosine. A talented team of scientists recently showed that two members of the DNA methyltransferase (DNMT) family, DNMT3a and DNMT3b are more than just methyltransferases; they fill a role as dehydroxymethylases as well. It has already […]

Redefining DNA Methylation in Cancer with Dr. Andrew Feinberg

August 1, 2012

Dr. Andrew Feinberg discusses how recent events are reshaping the way his team thinks about DNA methylation in cancer. This interview was shot on campus at Johns Hopkins University. This video was brought to you by epigenetics supporters at EMD Millipore. Redefining DNA Methylation in Cancer Well, there are a number of things I’m […]

Non-Coding RNAs and Drug Addiction

July 31, 2012

Although a lot of behavioral studies are out there on drug addiction, no one really knows how addiction develops at the molecular level. A new review by researchers in Miami describes lots of evidence from more than 80 studies suggesting that non-coding RNAs, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), might have a […]

RTL-P: Pinpoint 2’-O-methylation in RNAs

July 31, 2012

Yeah, it would be crazy to play hide-and-go-seek with a GPS, night-vision goggles, and a heat-sensing camera. But that’s kind of similar to the pricey, sophisticated laboratory gadgets that researchers currently have to use to spot 2’-O-methylation hiding on RNAs. Now, scientists in China have come up with a much simpler, less expensive way (called […]

Pol II Transcription Slows at 5-Formylcytosines (5caC) and 5-Carboxylcytosines (5fC)

July 31, 2012

It’s summertime—a time when you just want to take things slow. Researchers now report that 5-formylcytosines (5fCs) and 5-carboxylcytosines (5caCs) like to slow things down, no matter what the season. They say that these mods put the brakes on RNA Pol II transcription and make it less specific. Sure, researchers have known about 5fC and […]

Exploring the Genotype-Chromatin Structure-Disease Risk Connection

July 26, 2012

Its easy to obsess over little details, and want to understand every nuance of a subject that you’re passionate about, but sometimes it’s helpful to step back and get a broader perspective on what you’re working on. This review article from Richard Meagher and Kristofer Müssar at the University of Georgia does just that by […]

More Epigenomic Differences Found in Twins?

July 24, 2012

Twins may look alike, and even share identical genomes, but according to new studies, their epigenomes can be surprisingly different. Examination of the DNA methylation patterns in sets of twins revealed that early environmental conditions can alter epigenomes, and have a big impact on individual variability. A research effort headed up by Jeff Craig and […]

Guide: Quick Tips for ChIP Beginners

July 17, 2012

At Abcam we run quite a few ChIP assays and we interact with customers that run even more than us. Lately, we’ve noticed that more researchers are turning to ChIP for the first time as gene regulation studies continue to grow. So we thought we’d share a couple of quick tips for various aspects of […]

Pushing the Technology Frontier in Epigenetics Research with Dr. Andrew Feinberg

July 16, 2012

Dr. Andy Feinberg discusses what technology advances are needed in the field of epigenetics. This interview was shot on campus at Johns Hopkins University. This video was brought to you by epigenetics supporters at EMD Millipore Single Cell Analysis One of the areas I think is going to be really important is single-cell analysis. […]