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Epigenetic Marks Make the Long Distance Thing Look Easy

February 22, 2010

Even with all the advanced communications at our fingertips today, long distance relationships rarely work out, but it appears epigenetic silencing is an exception. Epigenetic silencing can spread to neighboring genomic regions through long-range epigenetic silencing (LRES) in cancer cells. In LRES, large blocks of genomic regions (like on the order of megabases) get silenced. […]

Transcription Factors Stand Up to the Methylation Machine

February 18, 2010

Sometimes the best defense is a good offense. That appears to be the case for transcription factors (TFs) that resist de novo DNA methylation by binding to their sites in CpG islands. Although this idea has been around for awhile, a team of German and American researchers led by Michael Rehli recently provided the first […]

CpG Methyltransferases Caught in the Act-and in Real Time

February 17, 2010

Being “caught in the act” isn’t usually a good thing, but catching DNA methyltransferases in the act is a very good thing for epigeneticists. A team at the University of Southampton (U.K.) now reports that they have developed a reproducible, real-time fluorescent assay that will help scientists understand how these enzymes regulate themselves, interact with […]

CSI’s Newest Crime-Solving Tool: miRNAs

February 17, 2010

The TV franchise CSI: Crime Scene Investigation makes it seem like analyzing biological samples in a criminal investigation is as simple as pushing a button on a fancy gizmo and having the results printed out within seconds. (Of course, they also solve complex mysteries in under an hour every week, so I guess you can’t […]

Nature and Nurture Walking the Same Path?

February 11, 2010

Ever notice how it gets more interesting when there’s more than just black or white, love or hate, good or evil? The real action seems to take place in the gray areas. It seems true for methylated alleles as well. A recent paper looking into genomic imprinting found new evidence that both genomic and environmental […]

State of Methylome Analysis: Genome-Wide Methylation Techniques Review

February 11, 2010

The State of the Union Address and the drama/commentaries that accompany it have come come and gone, but a fresh Nature Review produced by USC’s Peter Laird now provides the epigenetics community with a State of Methylome Analysis. For the epigenetics researcher, it is every bit as insightful but won’t take as much time to […]

Histone Mods Choose Alternative Splicing Lifestyle

February 8, 2010

We can’t say we were surprised to hear that histone mods lead an alternative lifestyle—not that there’s anything wrong with that. It’s been theoretically shown that nucleosomes and their histone marks are involved in splicing by crunching data from previous experiments. Now, scientists at NCI, the University of Toronto, and the University of Texas Health […]

Methylome Stays Fashionable Throughout Differentiation

February 5, 2010

Our fashion sense evolves as we do. Just as you may trade your flip-flops for a business suit as you climb the corporate ladder, DNA methylation changes its style in cells that become more committed. To size up these methylation changes during differentiation, researchers at the UCSD Department of Reproductive Medicine and GIS in Singapore […]

Self Service Transcription Lane Now Open for miRNAs

February 2, 2010

Many retailers have opened up self-service checkout lanes lately, which are great for those customers with just a few items, or don’t want to get stuck behind the old couple who still pays with paper checks. According to a recent report, when it comes to transcription, at least some miRNAs might have the option to […]

In Evolution, Change Is the Only (Epigenetic) Constant

February 1, 2010

Most of us are thrown for a loop when conditions suddenly change, but some are better able to cope than others (we still haven’t gotten used to the new Facebook format). A recent PNAS paper by Johns Hopkins’ epi-gurus Andrew Feinberg and Rafael Irizarry makes the case that some of this adaptability stems from stochastic […]

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