epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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ChIP Shows Cas9 Can Miss the Mark

June 10, 2014

Staying on target has always been the CRISPR/Cas9 claim to genome editing fame, leading to incredible breakthroughs in the application of this bacterial immune system to mammals and as a cure for inherited disease. But now a sharpshooting team from the University of Virginia have used a clever application of ChIP-Seq to show that sometimes Cas9 can cause off-target effects. […]

5hmU: Tet’s Newest Base on the Block

June 9, 2014

While Apple seems focused on reducing complexity, the epigenome just can’t stop increasing it. Researchers from the Ludwig-Maximilians-University in Munich have shown that Tet enzymes oxidize not only the methyl group of methyl-cytosine (mC) but also thymine (T). An analog to the traditional oxidation of 5mC to 5hydroxymethyl-cytosine (5hmC), this case generates hydroxymethyl-uracil (5hmU). By tracing metabolically stable isotopes […]

CTCF Prevents Cancerous Landscapes

May 26, 2014

This is the time of year to spruce up the garden, but a recent report has us thinking more about a DNA Methylation landscaper: CTCF. Epigenetic marks have long been associated with cancer and resarchers from the Fred Hutchinson Cancer Research Center (Seattle) have shown that when the epigenetic groundskeepers (i.e. CTCF) are short handed, the epigenetic […]

lncRNAs Give a Shout Out to Imprinted Genes

May 22, 2014

For a while there, it didn’t seem like long non-coding RNAS (lncRNAs) had very much to say on the subject of genomic imprinting. But some new evidence shows that lncRNAs have found their voice, shouting loud and clear as a cross-talk conduit between imprinted regions. Researchers from Hebrew University (Jerusalem) introduced a new concept into […]

DNA Methylation and Diet: A Lot to Chew On

May 7, 2014

Just in time for Mother’s Day, a new published report finds that a mother’s diet at the conception of her child causes life-long epigenetic differences in the metastable epialleles of the child with “permanent phenotypic consequences”. While it may seem that the “you are what you eat” card has been played to death to explain […]

Non-coding RNAs Reveal How Stress Can Be Inherited

May 7, 2014

Stress hits every one of us, like when the Heartbleed virus makes you have to go back and reset all of your online passwords. Recent evidence has already linked the DNA methylation and histone alterations left behind by stressful events to transgenerational epigenetic inheritance, but now, scientists from the Brain Research Institute in Switzerland have observed […]

Going ChIP-less Yields More Insights on Histone Code Combos

April 29, 2014

When it comes to studying chromatin structure and histone modifications, a new technique proves that sometime less really is more, ChIP-less that is. Antibodies for individual histone post-translational modifications (PTMs) have long been the star of chromatin technology, but PTMs often act in concert to form a dynamic histone code whose combinations can interfere with antibodies attempting to bind […]

Ancient History as Told by DNA Methylation

April 23, 2014

To some people ancient history is anything prior to Facebook, for others, it might mean pre-iPod, but this new study uses DNA methylation to look WAY back in time and analyze the beginnings of human evolution (And yes, that’s before the internet was invented). Using epigenomics to look back into pre-historic times has taught us […]

DNA Cubes May Take Genome Editing Outside the Box

April 22, 2014

Through the use of some creative chemistry researchers have devised DNA cubes that can deliver molecular packages with precision that would make FedEx jealous. A geometrically genius team from McGill University crafted a piece of DNA origami that will only release it’s molecular payload when triggered by a specific mRNA. Here’s how they did it: Cubes were […]

Kit Competition Reveals Hacks to Help Bisulfite Conversion

April 16, 2014

At first pass it may seem like all bisulfite conversion kits are essentially the same – and for the most part, that’s true. But according to a recently published evaluation, the conversion is all in the details, and if those are overlooked it can have a big impact on the results. Fortunately, researchers from the […]

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