epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

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Just Add HiDRO to Figure Out How Genomes Fold in Single Cells

September 14, 2023

Water hydrates and is essential for life—for plants, humans, and even fish. So, it’s fitting that a new technique called HiDRO takes high-throughput FISH to the next level to identify factors that help genomes fold in 3D at high throughput in single cells. Cohesin helps DNA form loops, which can then form topologically associated domains (TADs). […]

An Evolutionary and Epigenetic Tour-de-force Links DNA Methylation and Mammalian Aging

September 11, 2023

Have you climbed Mount Everest? Recorded a critically acclaimed album?? Written the great American novel??? These life-affirming feats of body and mind pale into insignificance when compared to the evolutionary and epigenetic tour-de-force reported in two recent papers based on mammalian DNA methylation datasets of colossal size and importance. An expeditionary force led by Steve […]

“Dynamite” Study Uses TNT To Destroy Epigenetic Memories in Human iPSCs

September 11, 2023

While lingering memories can represent unwelcome guests, destroying them with the power of dynamite may seem like overkill! However, a volatile new study now describes TNT or transient-naïve-treatment as a simple means of ridding human induced pluripotent stem cells (hiPSC) of their epigenetic memories and improving their therapeutic potential. An explosive epigenetic team headed by […]

Detecting Global Levels of 5mC and 5hmC at the Same Time—With Color

August 23, 2023

Color is exciting and fun—just look at Andy Warhol’s striking silkscreen paintings of Marilyn Monroe. Now, a new method uses bright red and green fluorescence to detect global levels of both methylated and hydroxymethylated cytosine (5mCs and 5hmCs) modifications of genomic DNA in the same straightforward assay, which could lead to easy and inexpensive clinical […]

Bringing in “Young Blood” Persistently and Systemically Slows Epigenetic Aging

August 22, 2023

Be it a football team, a book club, or an epigenetics lab, bringing in “young blood” can seriously improve quality in the short term, but does this effect endure? Now, a heterochronic parabiosis study reveals that long-term exposure to young blood induces persistent slowing of DNA methylation-based epigenetic aging and extends healthy lifespans in mice! […]

Altered Chromatin Accessibility Shows Why Aging Stem Cells Don’t Know if They’re Coming or Going!

August 13, 2023

Once young and carefree, the passing years creep up on us all and bring so many responsibilities and places to be that we don’t know whether we are coming or going! A busy new study shows that the chromatin accessibility and gene expression alterations that occur during aging impact neural stem cells (NSCs) in much […]

DM-Seq: A DM You’ll Want to Slide Into for Direct Methylation Sequencing of Cytosines

July 31, 2023

When someone slides into your DMs, it could mean that they are interested in you. Now, there’s a whole new meaning of “DM” for epigeneticists. Direct Methylation Sequencing (DM-seq) nondestructively maps 5mCs directly at single-base resolution with enzymes, and only needs nanograms of sample. There are already lots of ways to get at 5mC, including: Kohli’s […]

Histone Serotonylation Helps Neurons and Astrocytes Collaborate to Kick up a Stink!

July 19, 2023

We all have those seemingly innocent friends who end up causing trouble when they meet. Now, a study has revealed that astrocytes and neurons – generally the best of buddies – employ an epigenetic mechanism involving histone serotonylation when they get together and “kick up a stink”! A floral-smelling “bunch” of researchers headed by Benjamin […]

HiRES Lets You See Chromatin Structure and Transcription Clearly—At the Same Time

July 10, 2023

To see clearly, sometimes you just need a good pair of glasses or contacts. Now, Dong Xing’s lab (Peking University) has combined single cell Hi-C and RNA-seq to get a “Hi-RES” picture of chromatin and gene expression from the same cells simultaneously. Sure, separate Hi-C and RNA-seq data from different cells have been combined before, but […]

Dnmt3bas Is Inactive Dnmt3b’s Nemesis, Keeping Its Levels Low via Transcription and Splicing

July 10, 2023

The main character of many movies has a memorable nemesis who can’t help but try to bring them down and get in their way. Now, it turns out that the nemesis of the inactive Dntm3b isoform may just be development’s best friend. Before differentiation, Dnmt3b transcript levels are kept low, but get a boost at differentiation. […]

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